LRP1 Antibody (8G1): sc-57353

LRP1 Antibody (8G1) is a mouse monoclonal IgG1 antibody designed to detect Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1), also known as α2-Macroglobulin Receptor (α2MR). LRP1 is a multifunctional endocytic receptor localized primarily on the cell surface, where LRP1 plays a crucial role in internalizing a diverse range of ligands, including α2-Macroglobulin and apolipoprotein E (apoE). LRP1 is essential for processes such as lipid metabolism, protease clearance, and cellular signaling, which are vital for maintaining cellular homeostasis and function. LRP1 is predominantly expressed in key tissues such as the brain, liver, and lungs, highlighting LRP1′s importance in neurological health, metabolic regulation, and respiratory function. Additionally, LRP1 is implicated in the pathogenesis of Alzheimer′s disease, making LRP1 a significant target for research into neurodegenerative disorders. Anti-LRP1 antibody (8G1) is raised against the full-length native human LRP1, specifically targeting the extracellular epitope on the 515 kDa alpha chain. LRP1 (8G1) antibody is recommended for use across multiple species, including mouse, rat, and human, and is compatible with various applications such as western blotting (WB), immunofluorescence (IF), immunohistochemistry (IHC), and flow cytometry (FCM). By providing reliable detection of LRP1, anti-LRP1 antibody (8G1) is an indispensable tool for researchers investigating the intricate roles of LRP1 in health and disease, facilitating advanced studies into cellular functions and therapeutic potential.

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LRP1 Antibody (8G1) References:

1. Is the LDL receptor-related protein involved in Alzheimer's disease?  |  Lambert, JC., et al. 1999. Neurogenetics. 2: 109-13. PMID: 10369887
2. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.  |  Trommsdorff, M., et al. 1999. Cell. 97: 689-701. PMID: 10380922
3. Functional domains of the very low density lipoprotein receptor: molecular analysis of ligand binding and acid-dependent ligand dissociation mechanisms.  |  Mikhailenko, I., et al. 1999. J Cell Sci. 112 (Pt 19): 3269-81. PMID: 10504332
4. The second and fourth cluster of class A cysteine-rich repeats of the low density lipoprotein receptor-related protein share ligand-binding properties.  |  Neels, JG., et al. 1999. J Biol Chem. 274: 31305-11. PMID: 10531329
5. The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors.  |  Bacskai, BJ., et al. 2000. Proc Natl Acad Sci U S A. 97: 11551-6. PMID: 11016955
6. Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.  |  Kang, DE., et al. 2000. J Clin Invest. 106: 1159-66. PMID: 11067868
7. Role of rap in the biogenesis of lipoprotein receptors.  |  Bu, G. and Marzolo, MP. 2000. Trends Cardiovasc Med. 10: 148-55. PMID: 11239794
8. Apolipoprotein E synthesized by adipocyte and apolipoprotein E carried on lipoproteins modulate adipocyte triglyceride content.  |  Li, YH. and Liu, L. 2014. Lipids Health Dis. 13: 136. PMID: 25148848
9. Mitochondria Profoundly Influence Apolipoprotein E Biology.  |  Gabrielli, AP., et al. 2023. J Alzheimers Dis. 92: 591-604. PMID: 36776072
10. Peripheral apolipoprotein E proteins and their binding to LRP1 antagonize Alzheimer's disease pathogenesis in the brain during peripheral chronic inflammation.  |  Na, H., et al. 2023. Neurobiol Aging. 127: 54-69. PMID: 37060729
11. Role of apolipoprotein E in modulating neurite outgrowth: potential effect of intracellular apolipoprotein E.  |  Pitas, RE., et al. 1998. Biochem Soc Trans. 26: 257-62. PMID: 9649758
12. Three complement-type repeats of the low-density lipoprotein receptor-related protein define a common binding site for RAP, PAI-1, and lactoferrin.  |  Vash, B., et al. 1998. Blood. 92: 3277-85. PMID: 9787164

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LRP1 Antibody (8G1) has 16 citations in a variety of scientific publications.

Primary antibodies like Anti-LRP1 Antibody (8G1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LRP1 Antibody (8G1) Specifications

Alternate Product Name: LRP1

Product Clone Name: 8G1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: LRP1

Epitope Species: human

Product Reactivity/Detection: LRP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P), FCM

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 16 citations in various scientific publications

Available Conjugates/Forms for LRP1 Antibody (8G1): N/A