LRP Antibody (E-2): sc-390134

LRP Antibody (E-2) is a mouse monoclonal IgG2a antibody that detects LRP in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LRP, also known as the major vault protein (MVP), plays a crucial role in the multidrug resistance (MDR) phenotype observed in tumor cells, which often leads to treatment failure in cancer therapy. LRP is primarily located in the cytoplasm and is a key component of multimeric ribonucleoprotein complexes that transport untranslated RNA along cytoskeletal tracks, highlighting its importance in cellular transport mechanisms. LRP presence in various multidrug-resistant cancer cell lines and clinical samples underscores its significance in mediating drug resistance, potentially through its transport functions. Additionally, LRP has two alternative splice variants, with the long-LRP isoform being ubiquitously expressed across many normal tissues, which may influence its functional roles in both health and disease. The unique structural features of LRP, including its TATA-less promoter and specific binding sites, further contribute to its regulation and expression, making anti-LRP antibody (E-2) an essential tool for researchers studying drug resistance mechanisms in cancer.

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LRP Antibody (E-2) References:

1. The major vault protein (MVP), a new multidrug resistance associated protein, is frequently expressed in multiple myeloma.  |  Rimsza, LM., et al. 1999. Leuk Lymphoma. 34: 315-24. PMID: 10439368
2. Major vault protein is a substrate of endogenous protein kinases in CHO and PC12 cells.  |  Ehrnsperger, C. and Volknandt, W. 2001. Biol Chem. 382: 1463-71. PMID: 11727830
3. Disruption of the murine major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics.  |  Mossink, MH., et al. 2002. Cancer Res. 62: 7298-304. PMID: 12499273
4. Nuclear localization of the major vault protein in U373 cells.  |  Slesina, M., et al. 2005. Cell Tissue Res. 321: 97-104. PMID: 15902504
5. Up-regulation of major vault protein in the frontal cortex of patients with intractable frontal lobe epilepsy.  |  Liu, B., et al. 2011. J Neurol Sci. 308: 88-93. PMID: 21683962
6. Recruitment of the major vault protein by InlK: a Listeria monocytogenes strategy to avoid autophagy.  |  Dortet, L., et al. 2011. PLoS Pathog. 7: e1002168. PMID: 21829365
7. LRP-1: functions, signaling and implications in kidney and other diseases.  |  Lin, L. and Hu, K. 2014. Int J Mol Sci. 15: 22887-901. PMID: 25514242
8. Alteration of major vault protein in human glioblastoma and its relation with EGFR and PTEN status.  |  Navarro, L., et al. 2015. Neuroscience. 297: 243-51. PMID: 25869624
9. Major Vault Protein, a Candidate Gene in 16p11.2 Microdeletion Syndrome, Is Required for the Homeostatic Regulation of Visual Cortical Plasticity.  |  Ip, JPK., et al. 2018. J Neurosci. 38: 3890-3900. PMID: 29540554
10. Major vault protein is a direct target of Notch1 signaling and contributes to chemoresistance in triple-negative breast cancer cells.  |  Xiao, YS., et al. 2019. Cancer Lett. 440-441: 156-167. PMID: 30336197

The preferred LRP antibody is LRP Antibody (1014): sc-23916.