LRG1 Antibody (H-11): sc-393000
- LRG1 Antibody (H-11) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 268-295 near the C-terminus of LRG1 of mouse origin
- recommended for detection of LRG1 of mouse and rat origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LRG1 Antibody (H-11) for WB applications. These reagents are now offered in bundles with LRG1 Antibody (H-11) (see ordering information below).
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SEE ALSO...
LRG1 Antibody (H-11) is a mouse monoclonal IgG2b antibody that detects LRG1 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LRG1, or leucine-rich alpha-2-glycoprotein, is a 347 amino acid secreted protein characterized by eight leucine-rich repeats and one LRRCT domain, which play a crucial role in mediating protein-protein interactions, signal transduction, cell adhesion, and developmental processes. LRG1 is primarily found in plasma and is notably expressed during granulocyte differentiation, highlighting its importance in immune response and inflammation. LRG1 is encoded by a gene that spans nearly 3,000 bases on human chromosome 19p13.3, a region known for its high gene density and housing numerous immunoglobulin superfamily members, including various receptors vital for immune system function. The intricate structure of LRG1, with its unique leucine-rich repeat motifs, is essential for biological activity, as these motifs facilitate interactions with other proteins, thereby influencing various signaling pathways and cellular functions. Anti-LRG1 antibody (H-11) is an invaluable tool for researchers investigating LRG1′s roles in health and disease, particularly in immune responses and granulocyte biology.
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LRG1 Antibody (H-11) References:
- LRG1 May Accelerate the Progression of ccRCC via the TGF-β Pathway. | Hong, Q., et al. 2020. Biomed Res Int. 2020: 1285068. PMID: 32337221
- Serum LRG1 as a novel biomarker for cardioembolic stroke. | Zhang, M., et al. 2021. Clin Chim Acta. 519: 83-91. PMID: 33838125
- Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis. | Singhal, M., et al. 2021. Sci Transl Med. 13: eabe6805. PMID: 34516824
- LRG1 mediated by ATF3 promotes growth and angiogenesis of gastric cancer by regulating the SRC/STAT3/VEGFA pathway. | He, L., et al. 2022. Gastric Cancer. 25: 527-541. PMID: 35094168
- Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway. | Dritsoula, A., et al. 2022. Sci Rep. 12: 4867. PMID: 35318338
- LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation. | Choi, CHJ., et al. 2022. Elife. 11: PMID: 36346018
- LRG1 Promotes ECM Integrity by Activating the TGF-β Signaling Pathway in Fibroblasts. | Park, HN., et al. 2023. Int J Mol Sci. 24: PMID: 37569820
- Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway. | Chen, J., et al. 2024. Arch Biochem Biophys. 753: 109892. PMID: 38246328
- LRG1 promotes the apoptosis of pulmonary microvascular endothelial cells through KLK10 in chronic obstructive pulmonary disease. | Cheng, W., et al. 2024. Tob Induc Dis. 22: PMID: 38707515
- The disruptive role of LRG1 on the vasculature and perivascular microenvironment. | Dritsoula, A., et al. 2024. Front Cardiovasc Med. 11: 1386177. PMID: 38745756
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LRG1 Antibody (H-11) | sc-393000 | 200 µg/ml | $322.00 | |||
LRG1 Antibody (H-11): m-IgGκ BP-HRP Bundle | sc-535670 | 200 µg Ab; 40 µg BP | $361.00 | |||
LRG1 Antibody (H-11): m-IgG2b BP-HRP Bundle | sc-549469 | 200 µg Ab; 10 µg BP | $361.00 | |||
LRG1 (H-11) Neutralizing Peptide | sc-393000 P | 100 µg/0.5 ml | $69.00 |