LRG1 Antibody (D2): sc-517443

LRG1 Antibody (D2) is a mouse monoclonal IgG2a kappa light chain antibody that detects LRG1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). LRG1, or leucine-rich alpha-2-glycoprotein, is a 347 amino acid secreted protein characterized by eight leucine-rich repeats and one LRRCT domain, which play a crucial role in mediating protein-protein interactions, signal transduction, and cell adhesion. LRG1 presence in plasma is particularly significant as LRG1 is expressed during granulocyte differentiation, highlighting LRG1′s importance in immune response and inflammation. The gene encoding LRG1 is located on human chromosome 19p13.3, a region known for its high gene density, containing approximately 1,400 genes, including several members of the immunoglobulin superfamily. This chromosomal location is vital as it houses genes essential for various immune functions, including those involved in cell signaling and adhesion, which are critical for maintaining immune homeostasis and responding to pathogens. Anti-LRG1 antibody (D2) is an invaluable tool for researchers studying LRG1′s role in health and disease, providing insights into its function and potential as a biomarker in various conditions.

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LRG1 Antibody (D2) References:

1. LRG1 modulates invasion and migration of glioma cell lines through TGF-β signaling pathway.  |  Zhong, D., et al. 2015. Acta Histochem. 117: 551-8. PMID: 26049667
2. LRG1 downregulation in allergic airway disorders and its expression in peripheral blood and tissue cells.  |  Hao, L., et al. 2016. J Transl Med. 14: 202. PMID: 27378305
3. LRG1 promotes proliferation and inhibits apoptosis in colorectal cancer cells via RUNX1 activation.  |  Zhou, Y., et al. 2017. PLoS One. 12: e0175122. PMID: 28376129
4. The Clinical Prognostic Value of LRG1 in Esophageal Squamous Cell Carcinoma.  |  Wang, Y., et al. 2019. Curr Cancer Drug Targets. 19: 756-763. PMID: 30714525
5. Collaborative Regulation of LRG1 by TGF-β1 and PPAR-β/δ Modulates Chronic Pressure Overload-Induced Cardiac Fibrosis.  |  Liu, C., et al. 2019. Circ Heart Fail. 12: e005962. PMID: 31830829
6. LRG1 Suppresses Migration and Invasion of Esophageal Squamous Cell Carcinoma by Modulating Epithelial to Mesenchymal Transition.  |  Zhang, N., et al. 2020. J Cancer. 11: 1486-1494. PMID: 32047555
7. LRG1 Expression Is Elevated in the Eyes of Patients with Neovascular Age-Related Macular Degeneration.  |  Mundo, L., et al. 2021. Int J Mol Sci. 22: PMID: 34445590
8. LRG1 in pancreatic cancer cells promotes inflammatory factor synthesis and the angiogenesis of HUVECs by activating VEGFR signaling.  |  Cai, D., et al. 2022. J Gastrointest Oncol. 13: 400-412. PMID: 35284128
9. Structural basis of human LRG1 recognition by Magacizumab, a humanized monoclonal antibody with therapeutic potential.  |  Gutiérrez-Fernández, J., et al. 2022. Acta Crystallogr D Struct Biol. 78: 725-734. PMID: 35647920
10. The pan-cancer analysis of LRG1 and its potential role in kidney renal clear cell carcinoma.  |  Lei, Z., et al. 2025. RSC Med Chem.. PMID: 40008188

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LRG1 Antibody (D2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-LRG1 Antibody (D2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LRG1 Antibody (D2) Specifications

Alternate Product Name: LRG1

Product Clone Name: D2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 37-340

Epitope Target: LRG1

Epitope Species: human

Product Reactivity/Detection: LRG1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for LRG1 Antibody (D2): N/A

The preferred LRG1 antibody is LRG1 Antibody (C-4): sc-390920.