LMO7 Antibody (C-5): sc-365515

LMO7 Antibody (C-5) is a mouse monoclonal IgG2a antibody that detects LMO7 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LMO7 is a crucial nuclear factor characterized by a conserved LIM domain, which features a cysteine-rich zinc-binding motif that is integral to various transcription factors, including the LIM homeobox (LHX) proteins that play significant roles in the central nervous system. LMO7 consists of 1,349 amino acids and includes a distinctive zinc finger domain along with a 3-prime untranslated region that contains a short interspersed nucleotide element (SINE). Research has shown that LMO7 is predominantly expressed in the heart, lung, skeletal muscle, and kidney, with moderate expression levels in the liver, ovary, brain, pancreas, and testis, while showing little to no expression in the spleen. LMO7 functions as an afadin- and alpha-actinin-binding protein, effectively linking the nectin-afadin and E-cadherin-catenin systems through alpha-actinin, which is vital for maintaining cell adhesion and communication. This multifaceted role underscores LMO7′s significance in cellular processes and potential implications in various physiological and pathological conditions. Anti-LMO7 antibody (C-5) is an essential tool for researchers aiming to explore the intricate functions and interactions of this important protein.

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LMO7 Antibody (C-5) References:

1. Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes.  |  Holaska, JM., et al. 2006. Hum Mol Genet. 15: 3459-72. PMID: 17067998
2. LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response factor pathway and plays an important role in breast cancer cell migration.  |  Hu, Q., et al. 2011. Mol Cell Biol. 31: 3223-40. PMID: 21670154
3. Circulating exosomal microRNA-96 promotes cell proliferation, migration and drug resistance by targeting LMO7.  |  Wu, H., et al. 2017. J Cell Mol Med. 21: 1228-1236. PMID: 28026121
4. LMO7 exerts an effect on mitosis progression and the spindle assembly checkpoint.  |  Tzeng, YW., et al. 2018. Int J Biochem Cell Biol. 94: 22-30. PMID: 29158164
5. Identification of a Recurrent LMO7-BRAF Fusion in Papillary Thyroid Carcinoma.  |  He, H., et al. 2018. Thyroid. 28: 748-754. PMID: 29768105
6. LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease.  |  Karlsson, T., et al. 2018. Lung Cancer. 125: 174-184. PMID: 30429017
7. New Findings on LMO7 Transcripts, Proteins and Regulatory Regions in Human and Vertebrate Model Organisms and the Intracellular Distribution in Skeletal Muscle Cells.  |  Gomes, G., et al. 2021. Int J Mol Sci. 22: PMID: 34884689
8. Cytoskeletal fractionation identifies LMO7 as a positive regulator of fibroblast polarization and directed migration.  |  Bun, T., et al. 2023. Biochem Biophys Res Commun. 638: 58-65. PMID: 36442233
9. Exosome-transmitted circular RNA circ-LMO7 facilitates the progression of osteosarcoma by regulating miR-21-5p/ARHGAP24 axis.  |  Luo, A., et al. 2024. Cancer Biol Ther. 25: 2343450. PMID: 38742566
10. Immunoreactivity of LMO7 and other molecular markers as potential prognostic factors in oropharyngeal squamous cell carcinoma.  |  Israelsson, P., et al. 2024. BMC Oral Health. 24: 729. PMID: 38918827

The preferred LMO7 antibody is LMO7 Antibody (B-7): sc-376807.