LMO7 Antibody (B-7): sc-376807

LMO7 Antibody (B-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects LMO7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). LMO7 (B-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LIM-only (LMO) proteins, including LMO7, are essential nuclear factors characterized by a conserved LIM domain, which features a cysteine-rich zinc-binding motif found in numerous transcription factors, such as LIM homeobox (LHX) proteins that play critical roles in the development of the central nervous system. LMO7 consists of 1,349 amino acids and includes a distinctive zinc finger domain along with a 3-prime untranslated region that contains a short interspersed nucleotide element (SINE). Research has shown that LMO7 is predominantly expressed in the heart, lung, skeletal muscle, and kidney, with moderate expression levels in the liver, ovary, brain, pancreas, and testis, while showing little to no expression in the spleen. LMO7 functions as an afadin- and alpha-actinin-binding protein, facilitating the connection between the nectin-afadin and E-cadherin-catenin systems through alpha-actinin, which underscores its significance in cellular adhesion and signaling pathways.

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LMO7 Antibody (B-7) References:

1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.  |  Nagase, T., et al. 1998. DNA Res. 5: 355-64. PMID: 10048485
2. Identification of a family of human F-box proteins.  |  Cenciarelli, C., et al. 1999. Curr Biol. 9: 1177-9. PMID: 10531035
3. A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes.  |  Rozenblum, E., et al. 2002. Hum Genet. 110: 111-21. PMID: 11935316
4. An engineered 800 kilobase deletion of Uchl3 and Lmo7 on mouse chromosome 14 causes defects in viability, postnatal growth and degeneration of muscle and retina.  |  Semenova, E., et al. 2003. Hum Mol Genet. 12: 1301-12. PMID: 12761045
5. Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and alpha-actinin in epithelial cells.  |  Ooshio, T., et al. 2004. J Biol Chem. 279: 31365-73. PMID: 15140894
6. Systematic analysis and nomenclature of mammalian F-box proteins.  |  Jin, J., et al. 2004. Genes Dev. 18: 2573-80. PMID: 15520277
7. Transforming growth factor-beta1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells.  |  Nakamura, H., et al. 2005. Cancer Lett. 220: 95-9. PMID: 15737692
8. Differential expression and molecular characterisation of Lmo7, Myo1e, Sash1, and Mcoln2 genes in Btk-defective B-cells.  |  Lindvall, JM., et al. 2005. Cell Immunol. 235: 46-55. PMID: 16137664
9. LRIG1‑2 and LMO7 immunoreactivity in vulvar squamous cell carcinoma: Association with prognosis in relation to HPV‑DNA and p16INK4a status.  |  Stefansson, K., et al. 2019. Oncol Rep. 42: 142-150. PMID: 31059071
10. Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7.  |  Guérin, A., et al. 2021. Cell Host Microbe. 29: 1407-1420.e5. PMID: 34348092
11. Novel Long Non-Coding RNA (lncRNA) Transcript AL137782.1 Promotes the Migration of Normal Lung Epithelial Cells through Positively Regulating LMO7.  |  Zhang, Y., et al. 2023. Int J Mol Sci. 24: PMID: 37762205
12. Analysis of a human cDNA containing a tissue-specific alternatively spliced LIM domain.  |  Putilina, T., et al. 1998. Biochem Biophys Res Commun. 252: 433-9. PMID: 9826547

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LMO7 Antibody (B-7) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-LMO7 Antibody (B-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LMO7 Antibody (B-7) Specifications

Alternate Product Name: LMO7

Product Clone Name: B-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1321-1620

Epitope Target: LMO7

Epitope Species: mouse

Product Reactivity/Detection: LMO7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for LMO7 Antibody (B-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent