LMO3 Antibody (1A8): sc-517019

LMO3 Antibody (1A8) is a mouse monoclonal IgG2b kappa light chain antibody that detects LMO3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-LMO3 antibody (1A8) is available as the non-conjugated format. LMO3, also known as Rhombotin-3, RBTN3, RBTNL2, or RHOM3, is a 145 amino acid protein characterized by the presence of two LIM zinc-binding domains, which are crucial for transcriptional regulation across various tissues. LMO3 plays a vital role in gene expression regulation, and aberrant expression has been linked to neuroblastoma development and progression, a common pediatric cancer. LIM domains facilitate protein-protein interactions, allowing LMO3 to participate in complex regulatory networks that influence cellular processes. Located on human chromosome 12, LMO3 resides in a region associated with numerous genetic disorders, highlighting research significance not only for oncogenesis but also for broader genetic conditions.

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LMO3 Antibody (1A8) References:

1. Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization.  |  Shi, J., et al. 2001. Brain Res. 910: 29-37. PMID: 11489251
2. The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development.  |  Foroni, L., et al. 1992. J Mol Biol. 226: 747-61. PMID: 1507224
3. LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma.  |  Aoyama, M., et al. 2005. Cancer Res. 65: 4587-97. PMID: 15930276
4. Relations between multi-informant assessments of ADHD symptoms, DAT1, and DRD4.  |  Gizer, IR., et al. 2008. J Abnorm Psychol. 117: 869-80. PMID: 19025233
5. The highly related LIM factors, LMO1, LMO3 and LMO4, play different roles in the regulation of the pituitary glycoprotein hormone alpha-subunit (alpha GSU) gene.  |  Susa, T., et al. 2009. Biosci Rep. 30: 51-8. PMID: 19228115
6. The oncoprotein LMO3 interacts with calcium- and integrin-binding protein CIB.  |  Hui, L., et al. 2009. Brain Res. 1265: 24-9. PMID: 19236851
7. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13.  |  Boehm, T., et al. 1991. Proc Natl Acad Sci U S A. 88: 4367-71. PMID: 2034676
8. Oncogenic Lmo3 cooperates with Hen2 to induce hydrocephalus in mice.  |  Isogai, E., et al. 2015. Exp Anim. 64: 407-14. PMID: 26156403
9. Lmo3 deficiency in the mouse is associated with alterations in mood-related behaviors and a depression-biased amygdala transcriptome.  |  Reisinger, SN., et al. 2020. Psychoneuroendocrinology. 111: 104480. PMID: 31707294
10. LMO3 reprograms visceral adipocyte metabolism during obesity.  |  Wagner, G., et al. 2021. J Mol Med (Berl). 99: 1151-1171. PMID: 34018016
11. LMO3 promotes proliferation and metastasis of papillary thyroid carcinoma cells by regulating LIMK1-mediated cofilin and the β-catenin pathway.  |  Ling, Z., et al. 2022. Open Med (Wars). 17: 453-462. PMID: 35350839
12. LMO3 downregulation in PCa: A prospective biomarker associated with immune infiltration.  |  Xu, W., et al. 2022. Front Genet. 13: 945151. PMID: 36199576

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LMO3 Antibody (1A8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-LMO3 Antibody (1A8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LMO3 Antibody (1A8) Specifications

Alternate Product Name: LMO3

Product Clone Name: 1A8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 91-146

Epitope Target: LMO3

Epitope Species: human

Product Reactivity/Detection: LMO3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for LMO3 Antibody (1A8): N/A