LMO1 Antibody (790C2a): sc-130628

LMO1 Antibody (790C2a) is a mouse monoclonal IgG2b antibody that detects LMO1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-LMO1 antibody (790C2a) is available as a non-conjugated format. LMO1, also known as Rhombotin-1, plays a crucial role in regulating gene expression during neuronal differentiation and development. LMO1 is primarily located in the nucleus, where LMO1 functions as a transcriptional regulator by forming complexes with other proteins, including nuclear LIM interactor (NLI), which is essential for assembling transcriptional regulatory complexes. LMO1 interaction with NLI enhances stability and nuclear retention of LMO proteins, thereby influencing expression of target genes vital for neuronal identity and function. This regulatory mechanism is particularly important in adult central nervous system, where LMO1 is expressed in a cell type-specific manner and is differentially regulated by neuronal activity. Understanding LMO1 function and interactions is critical for elucidating LMO1′s role in neurodevelopmental processes and potential implications in neurological disorders.

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LMO1 Antibody (790C2a) References:

1. Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice.  |  Chervinsky, DS., et al. 1999. Mol Cell Biol. 19: 5025-35. PMID: 10373552
2. Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping.  |  Tse, E., et al. 1999. Mamm Genome. 10: 1089-94. PMID: 10556429
3. Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity.  |  Hinks, GL., et al. 1997. J Neurosci. 17: 5549-59. PMID: 9204936
4. Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis.  |  Kenny, DA., et al. 1998. Proc Natl Acad Sci U S A. 95: 11257-62. PMID: 9736723
5. Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI.  |  Semina, EV., et al. 1998. Mamm Genome. 9: 921-4. PMID: 9799849
6. Identification of the LMO4 gene encoding an interaction partner of the LIM-binding protein LDB1/NLI1: a candidate for displacement by LMO proteins in T cell acute leukaemia.  |  Grutz, G., et al. 1998. Oncogene. 17: 2799-803. PMID: 9840944
7. The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11).  |  Valge-Archer, V., et al. 1998. Oncogene. 17: 3199-202. PMID: 9872335