liver FBPase Antibody (G-7): sc-374396
- liver FBPase Antibody (G-7) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 209-239 within an internal region of liver FBPase of mouse origin
- Anti-liver FBPase Antibody (G-7) is recommended for detection of liver FBPase of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-liver FBPase Antibody (G-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for liver FBPase Antibody (G-7) for WB and IHC(P) applications. This reagent is now offered in a bundle with liver FBPase Antibody (G-7) (see ordering information below).
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SEE ALSO...
liver FBPase Antibody (G-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects liver FBPase in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). liver FBPase Antibody (G-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Fructose-1,6-bisphosphatase (FBPase) plays a crucial role in carbohydrate metabolism by catalyzing the conversion of fructose-1,6-bisphosphate into fructose 6-phosphate and inorganic phosphate, a key step in gluconeogenesis. This enzymatic activity maintains glucose homeostasis, especially during fasting states, and responds to allosteric effectors such as AMP, which inhibits FBPase activity, influencing metabolic pathways that govern energy production and storage. The liver isoform of FBPase consists of four identical subunits, and mutations in the FBP1 gene can lead to enzyme deficiency, resulting in serious metabolic disorders such as hypoglycemia and metabolic acidosis. Understanding FBPase function and regulation remains essential for exploring metabolic diseases and developing potential therapeutic strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
liver FBPase Antibody (G-7) References:
- Two newly identified genomic mutations in a Japanese female patient with fructose-1,6-bisphosphatase (FBPase) deficiency. | Matsuura, T., et al. 2002. Mol Genet Metab. 76: 207-10. PMID: 12126934
- Different sensitivities of mutants and chimeric forms of human muscle and liver fructose-1,6-bisphosphatases towards AMP. | Rakus, D., et al. 2003. Biol Chem. 384: 51-8. PMID: 12674499
- Interaction between muscle aldolase and muscle fructose 1,6-bisphosphatase results in the substrate channeling. | Rakus, D., et al. 2004. Biochemistry. 43: 14948-57. PMID: 15554702
- Nuclear localization of fructose 1,6-bisphosphatase in smooth muscle cells. | Gizak, A., et al. 2005. J Mol Histol. 36: 243-8. PMID: 16200456
- Purification of human liver fructose-1,6-bisphosphatase. | Dzugaj, A. and Kochman, M. 1980. Biochim Biophys Acta. 614: 407-12. PMID: 6250626
- Function, structure and evolution of fructose-1,6-bisphosphatase. | Marcus, F., et al. 1987. Arch Biol Med Exp. 20: 371-8. PMID: 8816077
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
liver FBPase Antibody (G-7) | sc-374396 | 200 µg/ml | $316.00 | |||
liver FBPase Antibody (G-7): m-IgG Fc BP-HRP Bundle | sc-525960 | 200 µg Ab; 10 µg BP | $354.00 | |||
liver FBPase Antibody (G-7) AC | sc-374396 AC | 500 µg/ml, 25% agarose | $416.00 | |||
liver FBPase Antibody (G-7) HRP | sc-374396 HRP | 200 µg/ml | $316.00 | |||
liver FBPase Antibody (G-7) FITC | sc-374396 FITC | 200 µg/ml | $330.00 | |||
liver FBPase Antibody (G-7) PE | sc-374396 PE | 200 µg/ml | $343.00 | |||
liver FBPase Antibody (G-7) Alexa Fluor® 488 | sc-374396 AF488 | 200 µg/ml | $357.00 | |||
liver FBPase Antibody (G-7) Alexa Fluor® 546 | sc-374396 AF546 | 200 µg/ml | $357.00 | |||
liver FBPase Antibody (G-7) Alexa Fluor® 594 | sc-374396 AF594 | 200 µg/ml | $357.00 | |||
liver FBPase Antibody (G-7) Alexa Fluor® 647 | sc-374396 AF647 | 200 µg/ml | $357.00 | |||
liver FBPase Antibody (G-7) Alexa Fluor® 680 | sc-374396 AF680 | 200 µg/ml | $357.00 | |||
liver FBPase Antibody (G-7) Alexa Fluor® 790 | sc-374396 AF790 | 200 µg/ml | $357.00 | |||
liver FBPase (G-7) Neutralizing Peptide | sc-374396 P | 100 µg/0.5 ml | $68.00 |