Liprin β2 Antibody (H-4): sc-514253
- Liprin β2 Antibody (H-4) is a mouse monoclonal IgG2b κ Liprin β2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 265-287 within an internal region of Liprin β2 of human origin
- Liprin beta 2 Antibody (H-4) is recommended for detection of Liprin β2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Liprin beta 2 Antibody (H-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Liprin β2 Antibody (H-4) for WB applications. These reagents are now offered in bundles with Liprin β2 Antibody (H-4) (see ordering information below).
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Liprin β2 Antibody (H-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects Liprin beta 2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Liprin β2 (H-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Liprin beta 2 protein plays a crucial role in cellular signaling and organization, particularly in synapse formation and axon guidance regulation, which is vital for proper neuronal connectivity and function. Liprin beta 2 protein is predominantly expressed in liver, kidney, intestine, heart, lung, and testis, with lower levels found in brain and thymus, highlighting importance in various physiological processes. Liprins, including Liprin beta 2, interact with members of leukocyte common antigen-related family of transmembrane protein tyrosine phosphatases, which are essential for cellular communication and development. Structural characteristics of Liprin beta 2, including multivalent nature and ability to form complex scaffolds, facilitate recruitment and anchoring of LAR phosphatases, thereby influencing signaling pathways critical for cell development and function. Liprin beta 2 exists in four isoforms due to splicing variants, with Isoform 1 representing full-length protein, while other isoforms exhibit specific deletions or alternative sequences that may affect functional roles.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Liprin β2 Antibody (H-4) References:
- Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1). | Kriajevska, M., et al. 2002. J Biol Chem. 277: 5229-35. PMID: 11836260
- Detailed genomic mapping and expression analyses of 12p amplifications in pancreatic carcinomas reveal a 3.5-Mb target region for amplification. | Heidenblad, M., et al. 2002. Genes Chromosomes Cancer. 34: 211-23. PMID: 11979555
- Identification and characterization of human PPFIA4 gene in silico. | Katoh, M. and Katoh, M. 2003. Int J Mol Med. 12: 1009-14. PMID: 14612982
- Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. | Serra-Pagès, C., et al. 1998. J Biol Chem. 273: 15611-20. PMID: 9624153
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Liprin β2 Antibody (H-4) | sc-514253 | 200 µg/ml | $316.00 | |||
Liprin β2 Antibody (H-4): m-IgG Fc BP-HRP Bundle | sc-531076 | 200 µg Ab; 10 µg BP | $354.00 | |||
Liprin β2 Antibody (H-4): m-IgGκ BP-HRP Bundle | sc-524664 | 200 µg Ab, 40 µg BP | $354.00 | |||
Liprin β2 Antibody (H-4): m-IgG2b BP-HRP Bundle | sc-550257 | 200 µg Ab; 10 µg BP | $354.00 | |||
Liprin β2 Antibody (H-4) AC | sc-514253 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Liprin β2 Antibody (H-4) HRP | sc-514253 HRP | 200 µg/ml | $316.00 | |||
Liprin β2 Antibody (H-4) FITC | sc-514253 FITC | 200 µg/ml | $330.00 | |||
Liprin β2 Antibody (H-4) PE | sc-514253 PE | 200 µg/ml | $343.00 | |||
Liprin β2 Antibody (H-4) Alexa Fluor® 488 | sc-514253 AF488 | 200 µg/ml | $357.00 | |||
Liprin β2 Antibody (H-4) Alexa Fluor® 546 | sc-514253 AF546 | 200 µg/ml | $357.00 | |||
Liprin β2 Antibody (H-4) Alexa Fluor® 594 | sc-514253 AF594 | 200 µg/ml | $357.00 | |||
Liprin β2 Antibody (H-4) Alexa Fluor® 647 | sc-514253 AF647 | 200 µg/ml | $357.00 | |||
Liprin β2 Antibody (H-4) Alexa Fluor® 680 | sc-514253 AF680 | 200 µg/ml | $357.00 | |||
Liprin β2 Antibody (H-4) Alexa Fluor® 790 | sc-514253 AF790 | 200 µg/ml | $357.00 | |||
Liprin β2 (H-4) Neutralizing Peptide | sc-514253 P | 100 µg/0.5 ml | $68.00 |