Lipin-2 Antibody (G-7): sc-514353

Lipin-2 Antibody (G-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects Lipin-2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Lipin-2 (G-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Lipin-2 plays a crucial role in lipid metabolism and is involved in the regulation of adipogenesis and energy homeostasis, making Lipin-2 essential for maintaining cellular energy balance and preventing metabolic disorders. Lipin-2 is predominantly located in the nucleus, where Lipin-2 functions as a transcriptional coactivator, influencing the expression of genes involved in lipid metabolism. Lipin-2 presence in various tissues, including brain, kidney, lung, heart, and skeletal muscles, highlights Lipin-2′s importance in diverse physiological processes. Notably, mutations in Lipin-2 can lead to Majeed syndrome, an autosomal recessive autoinflammatory disorder characterized by chronic multifocal osteomyelitis and congenital dyserythropoietic anemia, which manifests through symptoms such as bone and skin inflammation and recurrent fevers. Lipin-2 contains 11 single nucleotide polymorphisms (SNPs), further emphasizing the genetic variability that can influence Lipin-2′s function and associated pathologies.

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Lipin-2 Antibody (G-7) References:

1. Paraquat-induced gene expression in rat lung tissues using a differential display reverse transcription-polymerase chain reaction.  |  Tomita, M., et al. 2002. Arch Toxicol. 76: 530-7. PMID: 12242611
2. Genomic structure and organization of the high grade Myopia-2 locus (MYP2) critical region: mutation screening of 9 positional candidate genes.  |  Scavello, GS., et al. 2005. Mol Vis. 11: 97-110. PMID: 15723005
3. Biphasic expression of lipin suggests dual roles in adipocyte development.  |  Phan, J., et al. 2005. Drug News Perspect. 18: 5-11. PMID: 15753971
4. Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia.  |  Zhou, J. and Young, TL. 2005. Gene. 352: 10-9. PMID: 15862761
5. Homozygous mutations in LPIN2 are responsible for the syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia (Majeed syndrome).  |  Ferguson, PJ., et al. 2005. J Med Genet. 42: 551-7. PMID: 15994876
6. The fat and thin of lipin.  |  Reitman, ML. 2005. Cell Metab. 1: 5-6. PMID: 16054038
7. Lipin, a lipodystrophy and obesity gene.  |  Phan, J. and Reue, K. 2005. Cell Metab. 1: 73-83. PMID: 16054046
8. A missense mutation in pstpip2 is associated with the murine autoinflammatory disorder chronic multifocal osteomyelitis.  |  Ferguson, PJ., et al. 2006. Bone. 38: 41-7. PMID: 16122996
9. Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages.  |  Valdearcos, M., et al. 2012. J Biol Chem. 287: 10894-904. PMID: 22334674
10. Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation.  |  Lordén, G., et al. 2017. J Exp Med. 214: 511-528. PMID: 28031477
11. Lipin-2 degradation elicits a proinflammatory gene signature in macrophages.  |  Watahiki, A., et al. 2020. Biochem Biophys Res Commun. 524: 477-483. PMID: 32008742
12. Lipin-2 regulates the antiviral and anti-inflammatory responses to interferon.  |  de Pablo, N., et al. 2023. EMBO Rep. 24: e57238. PMID: 37929625

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Lipin-2 Antibody (G-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Lipin-2 Antibody (G-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Lipin-2 Antibody (G-7) Specifications

Alternate Product Name: Lipin-2

Product Clone Name: G-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 246-405

Epitope Target: Lipin-2

Epitope Species: human

Product Reactivity/Detection: Lipin-2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Lipin-2 Antibody (G-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin