LIN37 Antibody (G-3): sc-515686
- LIN37 Antibody (G-3) is a mouse monoclonal IgG1 κ LIN37 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-101 mapping at the N-terminus of LIN37 of human origin
- LIN37 Antibody (G-3) is recommended for detection of LIN37 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-LIN37 Antibody (G-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for LIN37 Antibody (G-3) for WB applications. These reagents are now offered in bundles with LIN37 Antibody (G-3) (see ordering information below).
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SEE ALSO...
LIN37 Antibody (G-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects LIN37 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-LIN37 antibody (G-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LIN37 protein, consisting of 246 amino acids, plays a crucial role in regulating cell cycle-dependent gene expression as a component of the DREAM complex, which is essential for maintaining cellular quiescence and proper cell cycle control. This complex functions by repressing genes that promote cell division, thereby preventing uncontrolled proliferation, which is particularly important in the context of cancer biology. LIN37 is encoded by a gene located on human chromosome 19q13.2, and mammalian homologs are vital for similar regulatory processes in higher organisms. The regulation of LIN37 and interactions with other proteins in the DREAM complex highlight LIN37′s significance in cellular signaling pathways, making LIN37 (G-3) monoclonal antibody an invaluable tool for researchers studying cell cycle regulation and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LIN37 Antibody (G-3) References:
- Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. | Korenjak, M., et al. 2004. Cell. 119: 181-93. PMID: 15479636
- Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. | Litovchick, L., et al. 2007. Mol Cell. 26: 539-51. PMID: 17531812
- LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. | Schmit, F., et al. 2007. Cell Cycle. 6: 1903-13. PMID: 17671431
- Ca2+-sensitive transcriptional regulation: direct DNA interaction by DREAM. | Sours-Brothers, S., et al. 2009. Front Biosci (Landmark Ed). 14: 1851-6. PMID: 19273168
- LIN54 is an essential core subunit of the DREAM/LINC complex that binds to the cdc2 promoter in a sequence-specific manner. | Schmit, F., et al. 2009. FEBS J. 276: 5703-16. PMID: 19725879
- Mutations that affect neural cell lineages and cell fates during the development of the nematode Caenorhabditis elegans. | Horvitz, HR., et al. 1983. Cold Spring Harb Symp Quant Biol. 48 Pt 2: 453-63. PMID: 6586368
- Ras pathways in Caenorhabditis elegans. | Kayne, PS. and Sternberg, PW. 1995. Curr Opin Genet Dev. 5: 38-43. PMID: 7749323
- EGF: new tricks for an old growth factor. | Carpenter, G. 1993. Curr Opin Cell Biol. 5: 261-4. PMID: 8507498
- LET-23-mediated signal transduction during Caenorhabditis elegans development. | Sternberg, PW., et al. 1995. Mol Reprod Dev. 42: 523-8. PMID: 8607985
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LIN37 Antibody (G-3) | sc-515686 | 200 µg/ml | $322.00 | |||
LIN37 Antibody (G-3): m-IgG Fc BP-HRP Bundle | sc-528055 | 200 µg Ab; 10 µg BP | $361.00 | |||
LIN37 Antibody (G-3): m-IgG1 BP-HRP Bundle | sc-533428 | 200 µg Ab; 20 µg BP | $361.00 | |||
LIN37 Antibody (G-3) AC | sc-515686 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LIN37 Antibody (G-3) HRP | sc-515686 HRP | 200 µg/ml | $322.00 | |||
LIN37 Antibody (G-3) FITC | sc-515686 FITC | 200 µg/ml | $336.00 | |||
LIN37 Antibody (G-3) PE | sc-515686 PE | 200 µg/ml | $349.00 | |||
LIN37 Antibody (G-3) Alexa Fluor® 488 | sc-515686 AF488 | 200 µg/ml | $364.00 | |||
LIN37 Antibody (G-3) Alexa Fluor® 546 | sc-515686 AF546 | 200 µg/ml | $364.00 | |||
LIN37 Antibody (G-3) Alexa Fluor® 594 | sc-515686 AF594 | 200 µg/ml | $364.00 | |||
LIN37 Antibody (G-3) Alexa Fluor® 647 | sc-515686 AF647 | 200 µg/ml | $364.00 | |||
LIN37 Antibody (G-3) Alexa Fluor® 680 | sc-515686 AF680 | 200 µg/ml | $364.00 | |||
LIN37 Antibody (G-3) Alexa Fluor® 790 | sc-515686 AF790 | 200 µg/ml | $364.00 |