LIFR Antibody (A-10): sc-515337

LIFR Antibody (A-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects LIFR protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LIFR Antibody (A-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LIFR protein plays a crucial role in mediating the effects of leukemia inhibitory factor (LIF), which is essential for various biological processes, including embryonic stem cell maintenance and differentiation, as well as the regulation of immune responses. LIFR is primarily located on the cell surface, where LIFR forms a signaling complex with gp130, a shared receptor component for several cytokines. This complex is vital for transducing signals that influence cell survival, proliferation, and differentiation. The interaction between LIF and LIFR is particularly important in the context of inflammation and tissue repair, as LIFR helps modulate the immune response and promote the survival of specific cell types during stress conditions. Understanding the function and signaling pathways of LIFR can provide insights into LIFR′s role in various diseases, including cancer and autoimmune disorders, making anti-LIFR antibody (A-10) a valuable tool for researchers studying these critical biological processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

LIFR Antibody (A-10) References:

1. Molecular cloning and expression of an IL-6 signal transducer, gp130.  |  Hibi, M., et al. 1990. Cell. 63: 1149-57. PMID: 2261637
2. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130.  |  Taga, T., et al. 1989. Cell. 58: 573-81. PMID: 2788034
3. Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.  |  Yamasaki, K., et al. 1988. Science. 241: 825-8. PMID: 3136546
4. Leukemia inhibitory factor promotes gastric cancer cell proliferation, migration, and invasion via the LIFR-Hippo-YAP pathway.  |  Bian, SB., et al. 2021. Ann N Y Acad Sci. 1484: 74-89. PMID: 32827446
5. Leukemia inhibitory factor receptor homodimerization mediated by acetylation of extracellular lysine promotes prostate cancer progression through the PDPK1/AKT/GCN5 axis.  |  Ding, Y., et al. 2022. Clin Transl Med. 12: e676. PMID: 35172032
6. Altered expression of leukemia inhibitory factor (LIF), LIFR, gp130, and IL11 in the embryo implantation site of rat model with prenatal androgen-induced polycystic ovary syndrome.  |  Javidan, M., et al. 2022. Biochem Biophys Res Commun. 605: 24-30. PMID: 35306361
7. Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction.  |  Hilton, DJ., et al. 1994. EMBO J. 13: 4765-75. PMID: 7957045
8. The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site.  |  Müllberg, J., et al. 1994. J Immunol. 152: 4958-68. PMID: 8176214
9. Cytokine signal transduction.  |  Kishimoto, T., et al. 1994. Cell. 76: 253-62. PMID: 8293462
10. LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor.  |  Davis, S., et al. 1993. Science. 260: 1805-8. PMID: 8390097
11. Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.  |  Murakami, M., et al. 1991. Proc Natl Acad Sci U S A. 88: 11349-53. PMID: 1662392
12. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase.  |  Murakami, M., et al. 1993. Science. 260: 1808-10. PMID: 8511589

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LIFR Antibody (A-10) has 20 citations in a variety of scientific publications.

Primary antibodies like Anti-LIFR Antibody (A-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LIFR Antibody (A-10) Specifications

Alternate Product Name: CD118

Product Clone Name: A-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 878-1097

Epitope Target: LIFR

Epitope Species: human

Product Reactivity/Detection: LIFR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 20 citations in various scientific publications

Available Conjugates/Forms for LIFR Antibody (A-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin