LHX6 Antibody (A-9): sc-271433
- LHX6 Antibody (A-9) is a mouse monoclonal IgG2a κ LHX6 antibody, cited in 24 publications, provided at 200 µg/ml
- raised against amino acids 1-75 mapping at the N-terminus of LHX6 of human origin
- LHX6 Antibody (A-9) is recommended for detection of LHX6 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-LHX6 Antibody (A-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-271433 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for LHX6 Antibody (A-9) for WB applications. This reagent is now offered in a bundle with LHX6 Antibody (A-9) (see ordering information below).
LHX6 Antibody (A-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects LHX6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LHX6 (A-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LHX6, also known as LIM homeobox 6, is a 363 amino acid nuclear protein characterized by two LIM zinc-binding domains and one homeobox DNA-binding domain, which are crucial for its function as a transcriptional regulator. LHX6 is specifically expressed in the brain and plays a significant role in the development and differentiation of lymphoid and neural cells, making LHX6 essential for proper neural patterning and motor neuron development. Notably, LHX6 is hypermethylated in head and neck carcinomas, suggesting LHX6′s potential as a novel tumor marker. Additionally, two isoforms of LHX6, LHX6.1A and LHX6.1B, arise from alternative splicing, further highlighting the complexity of LHX6′s regulation and function in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LHX6 Antibody (A-9) References:
- A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. | Kimura, N., et al. 1999. J Biochem. 126: 180-7. PMID: 10393337
- A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. | Gong, S., et al. 2003. Nature. 425: 917-25. PMID: 14586460
- Lhx6 regulates the migration of cortical interneurons from the ventral telencephalon but does not specify their GABA phenotype. | Alifragis, P., et al. 2004. J Neurosci. 24: 5643-8. PMID: 15201337
- Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus. | Choi, GB., et al. 2005. Neuron. 46: 647-60. PMID: 15944132
- LHX6 is a sensitive methylation marker in head and neck carcinomas. | Estécio, MR., et al. 2006. Oncogene. 25: 5018-26. PMID: 16732332
- Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. | Liodis, P., et al. 2007. J Neurosci. 27: 3078-89. PMID: 17376969
- NKX2.1 specifies cortical interneuron fate by activating Lhx6. | Du, T., et al. 2008. Development. 135: 1559-67. PMID: 18339674
- Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development. | Grigoriou, M., et al. 1998. Development. 125: 2063-74. PMID: 9570771
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LHX6 Antibody (A-9) | sc-271433 | 200 µg/ml | $322.00 | |||
LHX6 Antibody (A-9): m-IgG Fc BP-HRP Bundle | sc-525807 | 200 µg Ab; 10 µg BP | $361.00 | |||
LHX6 Antibody (A-9) X | sc-271433 X | 200 µg/0.1 ml | $322.00 | |||
LHX6 Antibody (A-9) AC | sc-271433 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LHX6 Antibody (A-9) HRP | sc-271433 HRP | 200 µg/ml | $322.00 | |||
LHX6 Antibody (A-9) FITC | sc-271433 FITC | 200 µg/ml | $336.00 | |||
LHX6 Antibody (A-9) PE | sc-271433 PE | 200 µg/ml | $349.00 | |||
LHX6 Antibody (A-9) Alexa Fluor® 488 | sc-271433 AF488 | 200 µg/ml | $364.00 | |||
LHX6 Antibody (A-9) Alexa Fluor® 546 | sc-271433 AF546 | 200 µg/ml | $364.00 | |||
LHX6 Antibody (A-9) Alexa Fluor® 594 | sc-271433 AF594 | 200 µg/ml | $364.00 | |||
LHX6 Antibody (A-9) Alexa Fluor® 647 | sc-271433 AF647 | 200 µg/ml | $364.00 | |||
LHX6 Antibody (A-9) Alexa Fluor® 680 | sc-271433 AF680 | 200 µg/ml | $364.00 | |||
LHX6 Antibody (A-9) Alexa Fluor® 790 | sc-271433 AF790 | 200 µg/ml | $364.00 |