LHX6 Antibody (A-9): sc-271433

LHX6 Antibody (A-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects LHX6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LHX6 (A-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LHX6, also known as LIM homeobox 6, is a 363 amino acid nuclear protein characterized by two LIM zinc-binding domains and one homeobox DNA-binding domain, which are crucial for its function as a transcriptional regulator. LHX6 is specifically expressed in the brain and plays a significant role in the development and differentiation of lymphoid and neural cells, making LHX6 essential for proper neural patterning and motor neuron development. Notably, LHX6 is hypermethylated in head and neck carcinomas, suggesting LHX6′s potential as a novel tumor marker. Additionally, two isoforms of LHX6, LHX6.1A and LHX6.1B, arise from alternative splicing, further highlighting the complexity of LHX6′s regulation and function in cellular processes.

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LHX6 Antibody (A-9) References:

1. A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains.  |  Kimura, N., et al. 1999. J Biochem. 126: 180-7. PMID: 10393337
2. A gene expression atlas of the central nervous system based on bacterial artificial chromosomes.  |  Gong, S., et al. 2003. Nature. 425: 917-25. PMID: 14586460
3. Lhx6 regulates the migration of cortical interneurons from the ventral telencephalon but does not specify their GABA phenotype.  |  Alifragis, P., et al. 2004. J Neurosci. 24: 5643-8. PMID: 15201337
4. Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus.  |  Choi, GB., et al. 2005. Neuron. 46: 647-60. PMID: 15944132
5. LHX6 is a sensitive methylation marker in head and neck carcinomas.  |  Estécio, MR., et al. 2006. Oncogene. 25: 5018-26. PMID: 16732332
6. Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes.  |  Liodis, P., et al. 2007. J Neurosci. 27: 3078-89. PMID: 17376969
7. NKX2.1 specifies cortical interneuron fate by activating Lhx6.  |  Du, T., et al. 2008. Development. 135: 1559-67. PMID: 18339674
8. Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development.  |  Grigoriou, M., et al. 1998. Development. 125: 2063-74. PMID: 9570771

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LHX6 Antibody (A-9) has 24 citations in a variety of scientific publications.

Primary antibodies like Anti-LHX6 Antibody (A-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LHX6 Antibody (A-9) Specifications

Alternate Product Name: LHX6

Product Clone Name: A-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-75

Epitope Target: LHX6

Epitope Species: human

Product Reactivity/Detection: LHX6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 24 citations in various scientific publications

Available Conjugates/Forms for LHX6 Antibody (A-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent