LHX2 Antibody (LHX2A12G1): sc-81311

LHX2 Antibody (LHX2A12G1) is a mouse monoclonal IgG1 antibody that detects LHX2 of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). LHX2 Antibody (LHX2A12G1) is available in a non-conjugated form, providing flexibility for various experimental needs. LHX2 plays a crucial role in the early patterning of the telencephalon, a critical process in brain development where the neuroepithelium differentiates into cortical tissue and cortical hem. This differentiation is vital for establishing the proper architecture and function of the cerebral cortex, which is essential for higher cognitive functions. LHX2, consisting of 389 amino acids, is part of the LIM homeodomain family, which is characterized by a unique cysteine-rich zinc-binding domain that facilitates protein-protein interactions. The expression of LHX2, along with other LIM domain factors, influences the fate of motor neuron subtypes during development, thereby guiding the formation of neural circuits. The human LHX2 gene is located on chromosome 9q33.3, and its proper function is critical for the development of the nervous system, making anti-LHX2 antibody (LHX2A12G1) an invaluable tool for researchers studying neurodevelopmental processes and related disorders.

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LHX2 Antibody (LHX2A12G1) References:

1. The LIM homeodomain protein dLim1 defines a subclass of neurons within the embryonic ventral nerve cord of Drosophila.  |  Lilly, B., et al. 1999. Mech Dev. 88: 195-205. PMID: 10534618
2. Requirement of LIM domains for LIM1 function in mouse head development.  |  Cheah, SS., et al. 2000. Genesis. 27: 12-21. PMID: 10862151
3. Genetic and epigenetic mechanisms contribute to motor neuron pathfinding.  |  Sharma, K., et al. 2000. Nature. 406: 515-9. PMID: 10952312
4. LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem.  |  Bulchand, S., et al. 2001. Mech Dev. 100: 165-75. PMID: 11165475
5. Lhx2, an evolutionarily conserved, multifunctional regulator of forebrain development.  |  Chou, SJ. and Tole, S. 2019. Brain Res. 1705: 1-14. PMID: 29522720
6. Lhx2 in germ cells suppresses endothelial cell migration in the developing ovary.  |  Singh, N., et al. 2022. Exp Cell Res. 415: 113108. PMID: 35337816
7. LHX2 facilitates the progression of nasopharyngeal carcinoma via activation of the FGF1/FGFR axis.  |  Xie, T., et al. 2022. Br J Cancer. 127: 1239-1253. PMID: 35864158
8. Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis.  |  Li, X., et al. 2022. Elife. 11: PMID: 36459481
9. LHX2 haploinsufficiency causes a variable neurodevelopmental disorder.  |  Schmid, CM., et al. 2023. Genet Med. 25: 100839. PMID: 37057675
10. LHX2 Is a Potential Biomarker and Associated with Immune Infiltration in Breast Cancer.  |  Zhang, Z., et al. 2023. Cancers (Basel). 15: PMID: 37345110
11. Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma.  |  Li, CP., et al. 2024. Cell Rep Med. 5: 101554. PMID: 38729157
12. Lhx2 specifically expressed in HSCs promotes liver regeneration and inhibits liver fibrosis.  |  Tao, J., et al. 2024. Hepatology.. PMID: 39693275

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LHX2 Antibody (LHX2A12G1) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-LHX2 Antibody (LHX2A12G1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LHX2 Antibody (LHX2A12G1) Specifications

Alternate Product Name: LHX2

Product Clone Name: LHX2A12G1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: LHX2

Epitope Species: human

Product Reactivity/Detection: LHX2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for LHX2 Antibody (LHX2A12G1): N/A