LHR Antibody (8G9A2): sc-293165

LHR Antibody (8G9A2) is a mouse monoclonal IgG1 antibody that detects luteinizing hormone/choriogonadotropin receptor (LHR) in both mouse and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). LHR is a critical seven transmembrane, G protein-coupled receptor glycoprotein predominantly expressed in the ovaries and testes, where LHR plays a vital role in regulating reproductive functions such as spermatogenesis and ovulation by stimulating steroid production. LHR presence in these reproductive organs is essential for maintaining hormonal balance and facilitating the physiological processes necessary for fertility. Additionally, LHR expression has been linked to the protective effects of pregnancy and the modulation of gonadotropin levels, which are crucial for sustaining estrogen and progesterone during the early stages of pregnancy. Notably, LHR expression in breast carcinoma has been associated with tumor differentiation, with LHR-positive tumors being more prevalent in well-differentiated cases among premenopausal women. The gene encoding human LHR is located on chromosome 2p21, highlighting LHR significance in both reproductive health and cancer biology.

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LHR Antibody (8G9A2) References:

1. Learning new tricks from an old dog: the processing of the intracellular precursor of the luteinizing hormone receptor (LHR) into the mature cell-surface LHR is a regulated process.  |  Ascoli, M. 2005. Endocrinology. 146: 3221-3. PMID: 16009970
2. Potential Leydig cell mitogenic signals generated by the wild-type and constitutively active mutants of the lutropin/choriogonadotropin receptor (LHR).  |  Ascoli, M. 2007. Mol Cell Endocrinol. 260-262: 244-8. PMID: 17055151
3. The Hmr and Lhr hybrid incompatibility genes suppress a broad range of heterochromatic repeats.  |  Satyaki, PR., et al. 2014. PLoS Genet. 10: e1004240. PMID: 24651406
4. The Hybrid Incompatibility Genes Lhr and Hmr Are Required for Sister Chromatid Detachment During Anaphase but Not for Centromere Function.  |  Blum, JA., et al. 2017. Genetics. 207: 1457-1472. PMID: 29046402
5. Characterization of Lhr-Core DNA helicase and manganese- dependent DNA nuclease components of a bacterial gene cluster encoding nucleic acid repair enzymes.  |  Ejaz, A. and Shuman, S. 2018. J Biol Chem. 293: 17491-17504. PMID: 30224353
6. MHR and NHR but not LHR were associated with coronary artery disease in patients with chest pain with controlled LDL-C.  |  Liu, M., et al. 2022. J Investig Med. 70: 1501-1507. PMID: 35817474
7. Performance Characterization of a Fully Transportable Mid-Infrared Laser Heterodyne Radiometer (LHR).  |  Shen, F., et al. 2023. Sensors (Basel). 23: PMID: 36679777
8. High-resolution oxygen-corrected laser heterodyne radiometer (LHR) for stratospheric and tropospheric wind field detection.  |  Li, J., et al. 2023. Opt Express. 31: 7850-7862. PMID: 36859908
9. Observed to expected lung area to head circumference ratio (O/E LHR) in fetuses with congenital anomalies of the kidney and urinary tract (CAKUT): assessment and evaluation as predictive factor for acute postnatal outcome-a single center study.  |  Sourouni, M., et al. 2023. Front Pediatr. 11: 1145907. PMID: 37404558
10. Luteinizing Hormone Receptor Mutation (LHRN316S) Causes Abnormal Follicular Development Revealed by Follicle Single-Cell Analysis and CRISPR/Cas9.  |  Zhang, C., et al. 2024. Interdiscip Sci. 16: 976-989. PMID: 39150470