LHPP Antibody (B-2): sc-376648

LHPP Antibody (B-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects LHPP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LHPP (B-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LHPP protein, also known as phospholysine phosphohistidine inorganic pyrophosphate phosphatase or HDHD2B, is a 270 amino acid protein that functions as a homodimer and belongs to the HAD-like hydrolase superfamily. LHPP protein plays a crucial role in regulating phosphate metabolism, which is essential for various cellular processes, including energy production and signal transduction. LHPP protein is predominantly expressed in the liver and kidney, with moderate expression in the brain, and is encoded by a gene located on chromosome 10, a region associated with several genetic disorders, including Charcot-Marie-Tooth disease and multiple endocrine neoplasia type 2. LHPP protein′s ability to modulate phosphate levels highlights its importance in maintaining cellular homeostasis and its potential implications in metabolic diseases, making anti-LHPP antibody (B-2) a valuable tool for researchers studying these pathways.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

LHPP Antibody (B-2) References:

1. Report of the third international workshop on human chromosome 10 mapping and sequencing 1999.  |  Deloukas, P., et al. 2000. Cytogenet Cell Genet. 90: 1-12. PMID: 11060438
2. Chromosome 10.  |  Gilbert, F. 2001. Genet Test. 5: 69-82. PMID: 11336406
3. Molecular cell biology of Charcot-Marie-Tooth disease.  |  Berger, P., et al. 2002. Neurogenetics. 4: 1-15. PMID: 12030326
4. The DNA sequence and comparative analysis of human chromosome 10.  |  Deloukas, P., et al. 2004. Nature. 429: 375-81. PMID: 15164054
5. Comparative mapping of human chromosome 10 to pig chromosomes 10 and 14.  |  Nonneman, D. and Rohrer, GA. 2004. Anim Genet. 35: 338-43. PMID: 15265077
6. Roles of FGF signaling in skeletal development and human genetic diseases.  |  Chen, L. and Deng, CX. 2005. Front Biosci. 10: 1961-76. PMID: 15769677
7. Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression.  |  Neff, CD., et al. 2009. Mol Psychiatry. 14: 621-30. PMID: 18268499
8. First report of ovarian dysgerminoma in Cowden syndrome with germline PTEN mutation and PTEN-related 10q loss of tumor heterozygosity.  |  Cho, MY., et al. 2008. Am J Surg Pathol. 32: 1258-64. PMID: 18594467
9. Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2.  |  Jabs, EW., et al. 1994. Nat Genet. 8: 275-9. PMID: 7874170

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LHPP Antibody (B-2) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-LHPP Antibody (B-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LHPP Antibody (B-2) Specifications

Alternate Product Name: LHPP

Product Clone Name: B-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 74-159

Epitope Target: LHPP

Epitope Species: human

Product Reactivity/Detection: LHPP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for LHPP Antibody (B-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin