LGI4 Antibody (KT18): sc-101488

LGI4 Antibody (KT18) is a rat monoclonal IgG1 antibody that detects the LGI4 protein of mouse origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-LGI4 antibody (KT18) is available as a non-conjugated format. LGI4, or leucine-rich repeat LGI family member 4, is a 537 amino acid secreted glycosylated protein that plays a crucial role in the nervous system, where LGI4 is predominantly expressed. LGI4 is essential for myelination and axon segregation, as evidenced by studies showing that siRNA knockdown of LGI4 in Schwann cells leads to inhibited myelination. The importance of LGI4 extends beyond structural roles; LGI4 is also implicated in neurological disorders, as mutations in LGI4′s homolog LGI1 have been associated with temporal lobe epilepsy, suggesting potential influence on seizure pathology. Additionally, LGI4 is localized to the Golgi apparatus, endoplasmic reticulum, and vesicles, which is critical for function in cellular signaling and protein processing. Two isoforms of LGI4 are generated through alternative splicing, adding another layer of complexity to biological roles.

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LGI4 Antibody (KT18) References:

1. The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins.  |  Gu, W., et al. 2002. FEBS Lett. 519: 71-6. PMID: 12023020
2. A common protein interaction domain links two recently identified epilepsy genes.  |  Scheel, H., et al. 2002. Hum Mol Genet. 11: 1757-62. PMID: 12095917
3. The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders.  |  Staub, E., et al. 2002. Trends Biochem Sci. 27: 441-4. PMID: 12217514
4. ADPEAF mutations reduce levels of secreted LGI1, a putative tumor suppressor protein linked to epilepsy.  |  Senechal, KR., et al. 2005. Hum Mol Genet. 14: 1613-20. PMID: 15857855
5. Using gene-history and expression analyses to assess the involvement of LGI genes in human disorders.  |  Gu, W., et al. 2005. Mol Biol Evol. 22: 2209-16. PMID: 16014869
6. The claw paw mutation reveals a role for Lgi4 in peripheral nerve development.  |  Bermingham, JR., et al. 2006. Nat Neurosci. 9: 76-84. PMID: 16341215
7. Genetic polymorphisms and idiopathic generalized epilepsies.  |  Lucarini, N., et al. 2007. Pediatr Neurol. 37: 157-64. PMID: 17765802
8. LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11.  |  Sagane, K., et al. 2008. Int J Biol Sci. 4: 387-96. PMID: 18974846