LDH-A Antibody (F-3): sc-137244
- LDH-A Antibody (F-3) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 6-42 at the N-terminus of LDH-A of human origin
- recommended for detection of LDH-A of human origin by WB, IP, IF and ELISA; non cross-reactive with LDH-A of mouse or rat origin
- See LDH-A (E-9): sc-137243 for LDH-A antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for LDH-A Antibody (F-3) for WB applications. These reagents are now offered in bundles with LDH-A Antibody (F-3) (see ordering information below).
LDH-A Antibody (F-3) is a mouse monoclonal IgG1 antibody that detects lactate dehydrogenase A (LDH-A) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LDH-A plays a crucial role in cellular metabolism by catalyzing the conversion of pyruvate to L-lactate during anaerobic glycolysis, a process vital for energy production in tissues experiencing low oxygen levels, such as muscle during intense exercise. This enzymatic activity maintains the balance of NAD+/NADH and supports ATP regeneration, essential for cellular functions. LDH-A serves as a significant biomarker for various conditions, including germ cell tumors, and expression patterns provide insights into tissue-specific metabolic adaptations. The LDH-A gene is located on chromosome 11, and mutations or deficiencies can lead to metabolic disorders such as exertional myoglobinuria, highlighting LDH-A′s critical role in human health. Anti-LDH-A antibody (F-3) is an invaluable tool for researchers studying metabolic pathways, cancer biology, and related fields.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LDH-A Antibody (F-3) References:
- Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. | Fantin, VR., et al. 2006. Cancer Cell. 9: 425-34. PMID: 16766262
- LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis. | Wang, ZY., et al. 2012. Breast Cancer Res Treat. 131: 791-800. PMID: 21452021
- LDH-A influences hypoxia-inducible factor 1α (HIF1 α) and is critical for growth of HT29 colon carcinoma cells in vivo. | Langhammer, S., et al. 2011. Target Oncol. 6: 155-62. PMID: 21660559
- Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors. | Rizwan, A., et al. 2013. Clin Cancer Res. 19: 5158-69. PMID: 23833310
- Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells. | Yang, Y., et al. 2014. Oncotarget. 5: 11886-96. PMID: 25361010
- LDH-A promotes malignant progression via activation of epithelial-to-mesenchymal transition and conferring stemness in muscle-invasive bladder cancer. | Jiang, F., et al. 2016. Biochem Biophys Res Commun. 469: 985-92. PMID: 26721441
- A mitochondria targeting Mn nanoassembly of BODIPY for LDH-A, mitochondria modulated therapy and bimodal imaging of cancer. | Boison, D., et al. 2016. Colloids Surf B Biointerfaces. 147: 387-396. PMID: 27559997
- Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH-A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR. | Varma, G., et al. 2021. NMR Biomed. 34: e4560. PMID: 34086382
- Metabolic Effects of New Glucose Transporter (GLUT-1) and Lactate Dehydrogenase-A (LDH-A) Inhibitors against Chemoresistant Malignant Mesothelioma. | Franczak, MA., et al. 2023. Int J Mol Sci. 24: PMID: 37175477
- The Chemokine CXCL7 is Correlated with LDH-A and Predicts the Prognosis of Patients with Colorectal Cancer. | Liang, H., et al. 2024. Front Biosci (Landmark Ed). 29: 166. PMID: 38682188
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LDH-A Antibody (F-3) | sc-137244 | 200 µg/ml | $322.00 | |||
LDH-A Antibody (F-3): m-IgG Fc BP-HRP Bundle | sc-539966 | 200 µg Ab; 10 µg BP | $361.00 | |||
LDH-A Antibody (F-3): m-IgG1 BP-HRP Bundle | sc-541819 | 200 µg Ab; 20 µg BP | $361.00 | |||
LDH-A (F-3) Neutralizing Peptide | sc-137244 P | 100 µg/0.5 ml | $69.00 |