LCOR Antibody (C-4): sc-398636

LCOR Antibody (C-4) is a mouse monoclonal IgM antibody that detects LCOR (Ligand-dependent corepressor) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LCOR is a 433 amino acid transcriptional corepressor characterized by its LXXLL motif, nuclear localization signal, and helix-loop-helix domain, which are crucial for regulating gene expression. LCOR is predominantly expressed in both fetal and adult tissues, where LCOR plays a vital role in modulating nuclear receptor activity, particularly estrogen receptors ERα and ERβ, in the presence of estradiol. By acting as a molecular scaffold, LCOR facilitates the recruitment of various proteins involved in transcriptional repression to specific DNA regions, thereby influencing the transcriptional landscape in response to hormonal signals. Notably, LCOR′s activity is subject to inhibition by the histone deacetylase inhibitor trichostatin A, indicating a receptor-dependent mechanism of action that underscores LCOR′s importance in maintaining cellular homeostasis. Furthermore, LCOR operates within a negative feedback loop to attenuate hormone-induced transactivation, highlighting LCOR′s critical role in fine-tuning hormonal responses and ensuring proper physiological function. Anti-LCOR antibody (C-4) is an essential tool for researchers investigating the intricate regulatory mechanisms of gene expression and the role of corepressors in various biological processes.

The preferred LCOR antibody is LCOR Antibody (C-6): sc-377019.