Lck BP-1 Antibody (9): sc-135972

Lck BP-1 Antibody (9) is a mouse monoclonal IgG1 antibody that detects Lck BP-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Lck BP-1 is a novel signaling intermediate that plays a crucial role in T cell activation by associating directly with the Src homology 3 (SH3) domain of the Lck tyrosine kinase, which is essential for T cell receptor (TCR) signaling. This interaction is facilitated by two proline-rich regions within Lck BP-1, highlighting its importance in the modulation of T cell responses. Additionally, Lck BP-1 contains four tandem 37 amino acid repeats that form a putative helix-loop-helix DNA binding motif, suggesting a potential role in gene regulation following T cell activation. Notably, Lck BP-1 is tyrosine phosphorylated in T cells after TCR engagement, indicating its involvement in downstream signaling pathways that are critical for T cell proliferation and differentiation. Anti-Lck BP-1 antibody (9) is an invaluable tool for researchers studying T cell biology and the molecular mechanisms underlying immune responses.

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Lck BP-1 Antibody (9) References:

1. The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1.  |  Dai, KZ., et al. 2000. Immunogenetics. 51: 179-85. PMID: 10752626
2. The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis.  |  Dai, KZ., et al. 2001. Genes Immun. 2: 263-8. PMID: 11528519
3. Transcriptional activation of the SH2D2A gene is dependent on a cyclic adenosine 5'-monophosphate-responsive element in the proximal SH2D2A promoter.  |  Dai, KZ., et al. 2004. J Immunol. 172: 6144-51. PMID: 15128801
4. Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene.  |  Smerdel, A., et al. 2004. Genes Immun. 5: 310-2. PMID: 15129233
5. cDNA cloning of a rat orthologue of SH2D2A encoding T-cell-specific adaptor protein (TSAd): expression in T and NK cells.  |  Nejad, S., et al. 2004. Immunogenetics. 56: 338-42. PMID: 15300336
6. Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7.  |  Granum, S., et al. 2006. BMC Immunol. 7: 15. PMID: 16839418
7. Expression of SH2D2A in T-cells is regulated both at the transcriptional and translational level.  |  Kolltveit, KM., et al. 2008. Mol Immunol. 45: 2380-90. PMID: 18160104
8. The SH2D2A gene and susceptibility to multiple sclerosis.  |  Lorentzen, AR., et al. 2008. J Neuroimmunol. 197: 152-8. PMID: 18554728
9. RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development.  |  Verma, R., et al. 2014. J Exp Med. 211: 1715-22. PMID: 25092874
10. Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity.  |  Mukohara, F., et al. 2024. Proc Natl Acad Sci U S A. 121: e2320189121. PMID: 39167601

The preferred Lck BP-1 antibody is Lck BP-1 Antibody (B-8): sc-28382.