Langerin Antibody (H-4): sc-271272

Langerin Antibody (H-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Langerin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Langerin (H-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Langerin, also known as CD207, is a crucial type II transmembrane protein that plays a significant role in the immune system by facilitating the differentiation of Langerhans cells into Birbeck granules, which are essential for effective antigen presentation to T-cells. These granules, characterized by their unique superimposing and zippering membrane structure, are vital for the proper processing and presentation of antigens, thereby influencing the adaptive immune response. The presence of Langerin in various human tissues, including the spleen, lymph nodes, thymus, liver, lung, and heart, underscores its importance in immune surveillance and response. The human Langerin gene is located on chromosome 2p13 and encodes a protein consisting of 328 amino acids, highlighting its evolutionary conservation and functional significance in immune regulation.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Langerin Antibody (H-4) References:

1. The monoclonal antibody DCGM4 recognizes Langerin, a protein specific of Langerhans cells, and is rapidly internalized from the cell surface.  |  Valladeau, J., et al. 1999. Eur J Immunol. 29: 2695-704. PMID: 10508244
2. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules.  |  Valladeau, J., et al. 2000. Immunity. 12: 71-81. PMID: 10661407
3. Interleukin 15 skews monocyte differentiation into dendritic cells with features of Langerhans cells.  |  Mohamadzadeh, M., et al. 2001. J Exp Med. 194: 1013-20. PMID: 11581322
4. Dermal-resident CD14+ cells differentiate into Langerhans cells.  |  Larregina, AT., et al. 2001. Nat Immunol. 2: 1151-8. PMID: 11702065
5. Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues.  |  Valladeau, J., et al. 2002. J Immunol. 168: 782-92. PMID: 11777972
6. Identification and expression of mouse Langerin (CD207) in dendritic cells.  |  Takahara, K., et al. 2002. Int Immunol. 14: 433-44. PMID: 11978773

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Langerin Antibody (H-4) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Langerin Antibody (H-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Langerin Antibody (H-4) Specifications

Alternate Product Name: Langerin

Product Clone Name: H-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-200

Epitope Target: Langerin

Epitope Species: human

Product Reactivity/Detection: Langerin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Langerin Antibody (H-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin