LAMP-2 Antibody (6A430): sc-71492
- LAMP-2 Antibody (6A430) is a rat monoclonal IgG1, cited in 9 publications, provided at 200 µg/ml
- epitope mapping to immunoadsorbent purified mouse macrophage glycoprotein fraction
- recommended for detection of LAMP-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin, FITC, Alexa Fluor® 488 or Alexa Fluor® 647 for IF, IHC(P) and FCM
- See LAMP-2 (ABL-93): sc-20004 for LAMP-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for LAMP-2 Antibody (6A430). This work is in progress.
LAMP-2 Antibody (6A430) is a rat monoclonal IgG1 antibody targeting an epitope mapped to an immunoadsorbent-purified mouse macrophage glycoprotein fraction, with reactivity in mouse, rat, and human species. LAMP-2 monoclonal antibody (6A430) is validated for applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). LAMP-2, also known as CD107B, is a glycosylated type I transmembrane protein found primarily on the lysosomal membrane, where LAMP-2 plays a crucial role in lysosomal integrity and autophagy. LAMP-2 facilitates the fusion of autophagosomes with lysosomes and interacts with key proteins involved in intracellular trafficking, such as Rab7, which regulates late endosome to lysosome transport. LAMP-2 also associates with lysosomal enzymes like cathepsins, supporting their stability and activity within the acidic lysosomal environment. Additionally, LAMP-2′s interaction with mannose-6-phosphate receptors highlights LAMP-2′s role in the sorting and delivery of hydrolases to lysosomes. Dysregulation of LAMP-2 expression or LAMP-2′s interactions can lead to lysosomal storage disorders such as Danon disease and is implicated in tumor progression due to LAMP-2′s role in cellular adhesion and invasion. Anti-LAMP-2 antibody (6A430) is a valuable resource for studying LAMP-2′s functional interactions and significance in lysosomal biology and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LAMP-2 Antibody (6A430) | sc-71492 | 200 µg/ml | $322.00 | |||
LAMP-2 Antibody (6A430) Alexa Fluor® 488 | sc-71492 AF488 | 200 µg/ml | $364.00 | |||
LAMP-2 Antibody (6A430) Alexa Fluor® 647 | sc-71492 AF647 | 200 µg/ml | $364.00 | |||
LAMP-2 Antibody (6A430) FITC | sc-71492 FITC | 200 µg/ml | $336.00 | |||
LAMP-2 Antibody (6A430) PE | sc-71492 PE | 200 µg/ml | $349.00 |