LAMP1 Antibody (H5G11): sc-18821
- LAMP1 Antibody (H5G11) is a mouse monoclonal IgG1 κ, cited in 93 publications, provided at 200 µg/ml
- raised against adherent spleen cells of human origin
- LAMP1 Antibody (H5G11) is recommended for detection of LAMP-1 of human origin by WB, IP, IF and IHC(P)
- Anti-LAMP1 Antibody (H5G11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for LAMP1 Antibody (H5G11) for WB and IHC(P) applications. This reagent is now offered in a bundle with LAMP1 Antibody (H5G11) (see ordering information below).
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LAMP-1 Antibody (H5G11) is a mouse monoclonal IgG1 kappa light chain antibody that detects LAMP-1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-LAMP-1 antibody (H5G11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LAMP-1, also known as CD107a, is a glycosylated type I membrane protein primarily located on the surface of lysosomes and late endosomes, playing a crucial role in cellular processes such as adhesion and the trafficking of lysosomal enzymes. LAMP-1′s presence on the surface of activated platelets suggests a significant function in the adhesive and prothrombotic properties of these cells, which is vital for wound healing and hemostasis. Additionally, LAMP-1 is involved in maintaining lysosomal acidity and protecting lysosomal membranes from autodigestion, with LAMP-1 expression levels increasing in lysosomal storage disorders, highlighting LAMP-1′s importance in cellular homeostasis and disease states. The unique sorting and transport mechanisms of LAMP-1 and LAMP-1′s interaction with other lysosomal proteins underscore LAMP-1′s critical role in cellular function and pathology, making LAMP-1 monoclonal antibody (H5G11) an essential tool for researchers studying lysosomal dynamics and related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LAMP1 Antibody (H5G11) References:
- Lamp-1 is upregulated in human glioblastoma cell lines induced to undergo apoptosis. | Chen, JW., et al. 2001. J Biomed Sci. 8: 365-74. PMID: 11455200
- Immunochemical analysis of CD107a (LAMP-1). | Parkinson-Lawrence, EJ., et al. 2005. Cell Immunol. 236: 161-6. PMID: 16168398
- Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease. | Barrachina, M., et al. 2006. Neuropathol Appl Neurobiol. 32: 505-16. PMID: 16972884
- Expression of the lysosomal-associated membrane protein-1 (LAMP-1) in astrocytomas. | Jensen, SS., et al. 2013. Int J Clin Exp Pathol. 6: 1294-305. PMID: 23826410
- Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage. | Cohnen, A., et al. 2013. Blood. 122: 1411-8. PMID: 23847195
- Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells. | Tan, KP., et al. 2016. Cell Death Dis. 7: e2347. PMID: 27560716
- The Major Lysosomal Membrane Proteins LAMP-1 and LAMP-2 Participate in Differentiation of C2C12 Myoblasts. | Sakane, H. and Akasaki, K. 2018. Biol Pharm Bull. 41: 1186-1193. PMID: 30068868
- E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by Promoting LAMP-1 Proteasomal Degradation. | Liu, W., et al. 2024. Adv Sci (Weinh). 11: e2309560. PMID: 39031743
- Lamp-1 does not acquire the large polylactosaminoglycans characteristic of F9 cells. | Romero, PA., et al. 1993. Biochem J. 296 (Pt 1): 253-7. PMID: 8250851
- Expression of Lamp-1 and Lamp-2 and their interactions with galectin-3 in human tumor cells. | Sarafian, V., et al. 1998. Int J Cancer. 75: 105-11. PMID: 9426697
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LAMP1 Antibody (H5G11) | sc-18821 | 200 µg/ml | $322.00 | |||
LAMP1 Antibody (H5G11): m-IgG1 BP-HRP Bundle | sc-531640 | 200 µg Ab; 20 µg BP | $361.00 | |||
LAMP1 Antibody (H5G11) AC | sc-18821 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LAMP1 Antibody (H5G11) HRP | sc-18821 HRP | 200 µg/ml | $322.00 | |||
LAMP1 Antibody (H5G11) FITC | sc-18821 FITC | 200 µg/ml | $336.00 | |||
LAMP1 Antibody (H5G11) PE | sc-18821 PE | 200 µg/ml | $349.00 | |||
LAMP1 Antibody (H5G11) Alexa Fluor® 488 | sc-18821 AF488 | 200 µg/ml | $364.00 | |||
LAMP1 Antibody (H5G11) Alexa Fluor® 546 | sc-18821 AF546 | 200 µg/ml | $364.00 | |||
LAMP1 Antibody (H5G11) Alexa Fluor® 594 | sc-18821 AF594 | 200 µg/ml | $364.00 | |||
LAMP1 Antibody (H5G11) Alexa Fluor® 647 | sc-18821 AF647 | 200 µg/ml | $364.00 | |||
LAMP1 Antibody (H5G11) Alexa Fluor® 680 | sc-18821 AF680 | 200 µg/ml | $364.00 | |||
LAMP1 Antibody (H5G11) Alexa Fluor® 790 | sc-18821 AF790 | 200 µg/ml | $364.00 |