Laminin-R Antibody (16): sc-101517
- Laminin-R Antibody (16) is a mouse monoclonal IgG2a κ, cited in 3 publications, provided at 200 µg/ml
- raised against recombinant Laminin-R of human origin
- recommended for detection of Laminin-R of human origin by WB, IP and ELISA
- See Laminin-R (H-2): sc-74515 for Laminin-R antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Laminin-R Antibody (16) for WB applications. These reagents are now offered in bundles with Laminin-R Antibody (16) (see ordering information below).
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Laminin-R Antibody (16) is a mouse monoclonal IgG2a light chain antibody that detects Laminin-R in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Laminin-R, also known as colon carcinoma laminin-binding protein, plays a crucial role in cell adhesion and migration, particularly in cancer progression. Anti-Laminin-R antibody (16) targets a protein primarily located in the cell membrane and integral to lysosomal membrane formation, allowing lysosomes to effectively attach to Laminin-coated surfaces. Laminin-R levels are significantly elevated in aggressive carcinomas, with expression nine times higher in colon carcinoma compared to adjacent normal colonic epithelium. This upregulation indicates involvement in tumorigenesis and highlights potential as a biomarker for cancer diagnosis and prognosis. Laminin-R′s interaction with other extracellular matrix proteins, such as fibronectin and vitronectin, underscores importance in maintaining cellular architecture and facilitating communication between cells and their microenvironment. Anti-Laminin-R antibody (16) serves as an essential tool for researchers investigating cancer progression mechanisms and cell adhesion roles in tumor biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Laminin-R Antibody (16) References:
- The association of a single nucleotide polymorphism in the promoter region of the LAMA1 gene with susceptibility to Chinese high myopia. | Zhao, YY., et al. 2011. Mol Vis. 17: 1003-10. PMID: 21541277
- MicroRNA-202 inhibits tumor progression by targeting LAMA1 in esophageal squamous cell carcinoma. | Meng, X., et al. 2016. Biochem Biophys Res Commun. 473: 821-827. PMID: 27045085
- Increased Expression of Laminin Subunit Alpha 1 Chain by dCas9-VP160. | Perrin, A., et al. 2017. Mol Ther Nucleic Acids. 6: 68-79. PMID: 28325301
- TGFB1 and LAMA1 gene polymorphisms in children with high myopia. | Biler, ED., et al. 2018. Pak J Med Sci. 34: 463-467. PMID: 29805427
- LAMA1 variants were identified Joubert syndrome patient. | Noguchi, Y., et al. 2022. Pediatr Int. 64: e14980. PMID: 35224822
- Variability of retinopathy consequent upon novel mutations in LAMA1. | Schiff, ER., et al. 2022. Ophthalmic Genet. 43: 671-678. PMID: 35616092
- Effects of experimental glaucoma in Lama1nmf223 mutant mice. | Madhoun, S., et al. 2023. Exp Eye Res. 226: 109341. PMID: 36476399
- Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population. | Zhang, S., et al. 2023. J Oncol. 2023: 6922909. PMID: 36824663
- CRISPRa-induced upregulation of human LAMA1 compensates for LAMA2-deficiency in Merosin-deficient congenital muscular dystrophy. | Arockiaraj, AI., et al. 2023. bioRxiv.. PMID: 36945402
- Lama1 upregulation prolongs the lifespan of the dyH/dyH mouse model of LAMA2-related congenital muscular dystrophy. | Liu, Y., et al. 2024. J Genet Genomics. 51: 1066-1078. PMID: 38777118
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Laminin-R Antibody (16) | sc-101517 | 200 µg/ml | $322.00 | |||
Laminin-R Antibody (16): m-IgG Fc BP-HRP Bundle | sc-539773 | 200 µg Ab; 10 µg BP | $361.00 | |||
Laminin-R Antibody (16): m-IgG2a BP-HRP Bundle | sc-546782 | 200 µg Ab; 10 µg BP | $361.00 |