Laminin γ-1 Antibody (D18): sc-59846

Laminin γ-1 Antibody (D18) is a mouse monoclonal IgG2a light chain antibody that detects Laminin γ-1 in mouse, rat, and human samples through immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Laminin γ-1 plays a crucial role in the formation and maintenance of basement membranes, which are vital for tissue integrity and cellular functions. These specialized extracellular matrices not only provide structural support but also influence various cellular processes such as proliferation, migration, and differentiation. Laminin γ-1 is composed of three distinct chains—α, β, and γ—that form a heterotrimer, allowing for diverse interactions with other matrix components and cell surface receptors. This structural complexity is essential for the self-assembly of laminins into functional networks that stabilize tissue architecture. Laminin γ-1 is widely expressed across different tissues, particularly in those that produce basement membranes, and proper function is critical for maintaining the integrity of epithelial and endothelial layers. Disruptions in Laminin γ-1 expression or function can lead to various pathological conditions, highlighting its importance in both health and disease. Anti-Laminin γ-1 antibody (D18) is an invaluable tool for researchers studying the dynamics of basement membrane biology and its implications in tissue development and repair.

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Laminin γ-1 Antibody (D18) References:

1. Identification of endothelial cell binding sites on the laminin gamma 1 chain.  |  Ponce, ML., et al. 1999. Circ Res. 84: 688-94. PMID: 10189356
2. bcn-1 Element-dependent activation of the laminin gamma 1 chain gene by the cooperative action of transcription factor E3 (TFE3) and Smad proteins.  |  Kawata, Y., et al. 2002. J Biol Chem. 277: 11375-84. PMID: 11801598
3. Laminin gamma 1 chain peptide, C-16 (KAFDITYVRLKF), promotes migration, MMP-9 secretion, and pulmonary metastasis of B16-F10 mouse melanoma cells.  |  Kuratomi, Y., et al. 2002. Br J Cancer. 86: 1169-73. PMID: 11953867
4. Entactin and laminin gamma 1-chain gene expression in the early chick embryo.  |  Zagris, N., et al. 2005. Int J Dev Biol. 49: 65-70. PMID: 15744670
5. Plasmin-mediated degradation of laminin gamma-1 is critical for ethanol-induced neurodegeneration.  |  Skrzypiec, AE., et al. 2009. Biol Psychiatry. 66: 785-94. PMID: 19577227
6. Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.  |  Mokkapati, S., et al. 2011. J Biol Chem. 286: 1911-8. PMID: 21084308
7. Autoantibodies Against Multiple Epitopes in Bp180 and Laminin Gamma-1 in Subepidermal Blistering Skin Disease Associated with Psoriatic Erythroderma.  |  Goto-Hamano, H., et al. 2015. Indian J Dermatol. 60: 521. PMID: 26538726
8. Integrin subunit β1 and laminin γ1 chain expression: a potential prognostic biomarker in cervical cancer.  |  Zacapala-Gómez, AE., et al. 2020. Biomark Med. 14: 1461-1471. PMID: 32845182
9. Cloning of rat laminin gamma 1-chain gene promoter reveals motifs for recognition of multiple transcription factors.  |  O'Neill, BC., et al. 1997. Am J Physiol. 273: F411-20. PMID: 9321914
10. Inducible transcriptional activity of bcn-1 element from laminin gamma1-chain gene promoter in renal and nonrenal cells.  |  Suzuki, H., et al. 1998. Am J Physiol. 275: F518-26. PMID: 9755123

The preferred Laminin γ-1 antibody is Laminin γ-1 Antibody (B-4): sc-13144.