Laminin β-3 Antibody (A-6): sc-133178

Laminin β-3 Antibody (A-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Laminin beta-3 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Laminin beta-3 antibody (A-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Laminin beta-3, a key component of the extracellular matrix, plays a vital role in cell adhesion, differentiation, and migration, which are essential processes during tissue development and repair. Anti-Laminin beta-3 antibody (A-6) recognizes a protein primarily located in the basal lamina, a specialized layer of the extracellular matrix that underlies epithelial and endothelial cells, providing structural support and influencing cellular behavior. Laminin beta-3 presence in the basal lamina is crucial for maintaining tissue integrity and facilitating communication between cells and their environment. Anti-Laminin beta-3 antibody (A-6) targets a protein that interacts with various receptors, including integrins and dystroglycan, which are important for signaling pathways that regulate cell survival and proliferation. Understanding Laminin beta-3 function and localization is essential for elucidating its role in developmental biology and its implications in diseases such as cancer and muscular dystrophies.

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Laminin β-3 Antibody (A-6) References:

1. Co-expression of laminin β3 and γ2 chains and epigenetic inactivation of laminin α3 chain in gastric cancer.  |  Ii, M., et al. 2011. Int J Oncol. 39: 593-9. PMID: 21617852
2. microRNA-329 suppresses epithelial-to-mesenchymal transition and lymph node metastasis in bile duct cancer by inhibiting laminin subunit beta 3.  |  Liao, CH., et al. 2019. J Cell Physiol. 234: 17786-17799. PMID: 30887508
3. Endometrial laminin subunit beta-3 expression associates with reproductive outcome in patients with repeated implantation failure.  |  Li, T., et al. 2021. J Assist Reprod Genet. 38: 1835-1842. PMID: 33715134
4. Thyroxine-dependent regulation of integrin-laminin interactions in astrocytes.  |  Farwell, AP., et al. 1995. Endocrinology. 136: 3909-15. PMID: 7649099
5. The laminins.  |  Timpl, R. and Brown, JC. 1994. Matrix Biol. 14: 275-81. PMID: 7827749
6. Basal lamina assembly.  |  Yurchenco, PD. and O'Rear, JJ. 1994. Curr Opin Cell Biol. 6: 674-81. PMID: 7833047
7. Laminins: a family of diverse multifunctional molecules of basement membranes.  |  Aumailley, M. and Krieg, T. 1996. J Invest Dermatol. 106: 209-214. PMID: 8601717
8. Mechanism of laminin chain assembly into a triple-stranded coiled-coil structure.  |  Nomizu, M., et al. 1996. Biochemistry. 35: 2885-93. PMID: 8608125
9. Expression and function of integrin receptors for collagen and laminin in cultured human hepatic stellate cells.  |  Carloni, V., et al. 1996. Gastroenterology. 110: 1127-36. PMID: 8613002
10. Laminin interactions important for basement membrane assembly are promoted by zinc and implicate laminin zinc finger-like sequences.  |  Ancsin, JB. and Kisilevsky, R. 1996. J Biol Chem. 271: 6845-51. PMID: 8636109
11. Structure and function of basement membranes.  |  Engvall, E. 1995. Int J Dev Biol. 39: 781-7. PMID: 8645562
12. Laminin-binding integrins in tumor progression and metastasis.  |  Ziober, BL., et al. 1996. Semin Cancer Biol. 7: 119-28. PMID: 8773297

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Laminin β-3 Antibody (A-6) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-Laminin β-3 Antibody (A-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Laminin β-3 Antibody (A-6) Specifications

Alternate Product Name: Laminin β-3

Product Clone Name: A-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 873-1172

Epitope Target: Laminin β-3

Epitope Species: human

Product Reactivity/Detection: Laminin β-3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for Laminin β-3 Antibody (A-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin