Laminin α-5 Antibody (4B12): sc-130542
- Laminin α-5 Antibody (4B12) is a mouse monoclonal IgG1 λ Laminin α-5 antibody, cited in 1 publications, provided at 100 µg/ml
- raised against purified Laminin isolated from placenta of human origin
- recommended for detection of Laminin α-5 of human origin by IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Laminin α-5 Antibody (4B12). This work is in progress.
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Laminin α-5 Antibody (4B12) is a mouse monoclonal IgG1 antibody that detects Laminin α-5 protein of human origin by immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Laminin α-5 antibody (4B12) is available as a non-conjugated format, playing a crucial role in the formation and maintenance of basement membranes, essential components of the extracellular matrix. These basement membranes provide structural support to tissues and are involved in various cellular processes, including cell adhesion, differentiation, and migration. Laminin α-5 (4B12) monoclonal antibody recognizes a heterotrimer composed of α, β, and γ chains, which allows interaction with other matrix components and cell surface receptors, facilitating the assembly of the extracellular matrix. Proper functioning of Laminin α-5 is vital for tissue integrity and repair, as Laminin α-5 influences cellular behavior and tissue architecture. Laminin α-5 interacts with specific proteins such as integrins and dystroglycan, which are critical for cellular signaling and communication. The human Laminin α-5 gene is located on chromosome 20q13.33, highlighting genetic significance in health and disease.
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Laminin α-5 Antibody (4B12) References:
- Role of laminin isoforms in glomerular structure. | Hansen, K. and Abrass, CK. 1999. Pathobiology. 67: 84-91. PMID: 10023136
- Form and function: the laminin family of heterotrimers. | Colognato, H. and Yurchenco, PD. 2000. Dev Dyn. 218: 213-34. PMID: 10842354
- Transcriptional regulation of laminin gene expression. | Aberdam, D., et al. 2000. Microsc Res Tech. 51: 228-37. PMID: 11054873
- Laminin alpha 5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule. | Kikkawa, Y., et al. 2008. Exp Cell Res. 314: 2579-90. PMID: 18635166
- A dispensable role of oligodendrocyte-derived laminin-α5 in brain homeostasis and intracerebral hemorrhage. | Kang, M., et al. 2024. J Cereb Blood Flow Metab. 44: 611-623. PMID: 38241459
- Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance. | Nirwane, A., et al. 2024. Fluids Barriers CNS. 21: 18. PMID: 38383451
- A dispensable role of mural cell-derived laminin-α5 in intracerebral hemorrhage. | Ruan, J., et al. 2024. J Cereb Blood Flow Metab. 44: 1677-1690. PMID: 39053486
- The laminin family. | Tryggvason, K. 1993. Curr Opin Cell Biol. 5: 877-82. PMID: 8240830
- Role of laminin in endothelial cell recognition and differentiation. | Schnaper, HW., et al. 1993. Kidney Int. 43: 20-5. PMID: 8433560
- Domains of laminin. | Engvall, E. and Wewer, UM. 1996. J Cell Biochem. 61: 493-501. PMID: 8806072
- Laminin and the mechanism of neuronal outgrowth. | Luckenbill-Edds, L. 1997. Brain Res Brain Res Rev. 23: 1-27. PMID: 9063584
- Laminin isoforms and epithelial development. | Ekblom, M., et al. 1998. Ann N Y Acad Sci. 857: 194-211. PMID: 9917842
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Laminin α-5 Antibody (4B12) | sc-130542 | 100 µg/ml | $316.00 |