Laminin α-1 Antibody (F-8): sc-74417

Laminin α-1 Antibody (F-8) is a mouse monoclonal IgG1 antibody that detects Laminin α-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Laminin α-1 is a crucial component of basement membranes, which are specialized extracellular matrices that provide structural support and influence various cellular functions, including proliferation, migration, and differentiation. Laminin α-1 is a heterotrimer composed of α, β, and γ chain subunits, which allows for self-assembly and interaction with other matrix components, such as Type IV collagen and proteoglycans. This structural versatility is vital for maintaining tissue integrity and facilitating cell signaling. Notably, Laminin α-1 plays a significant role in the development and maintenance of epithelial tissues and is implicated in pathological conditions, including Alzheimer′s disease, where Laminin α-1 expression is found to be elevated in the frontal cortex. Anti-Laminin α-1 antibody (F-8) is an essential tool for researchers studying the dynamics of basement membranes and their impact on cellular behavior in health and disease.

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Laminin α-1 Antibody (F-8) References:

1. Differential expression of laminin alpha chains during proliferative and differentiation stages in a model for skin morphogenesis.  |  Fleischmajer, R., et al. 2000. Matrix Biol. 19: 637-47. PMID: 11102753
2. Laminin alpha-chain expression and basement membrane formation by MLE-15 respiratory epithelial cells.  |  Nguyen, NM., et al. 2002. Am J Physiol Lung Cell Mol Physiol. 282: L1004-11. PMID: 11943665
3. Laminin alpha-1, alpha-3, and alpha-5 chain expression in human prepubertal [correction of prepubetal] benign prostate glands and adult benign and malignant prostate glands.  |  Brar, PK., et al. 2003. Prostate. 55: 65-70. PMID: 12640662
4. Biological activities of homologous loop regions in the laminin alpha chain G domains.  |  Suzuki, N., et al. 2003. J Biol Chem. 278: 45697-705. PMID: 12933811
5. Bifunctional peptides derived from homologous loop regions in the laminin alpha chain LG4 modules interact with both alpha 2 beta 1 integrin and syndecan-2.  |  Yokoyama, F., et al. 2005. Biochemistry. 44: 9581-9. PMID: 16008343
6. Chain-specific heparin-binding sequences in the laminin alpha chain LG45 modules.  |  Hozumi, K., et al. 2009. Biochemistry. 48: 5375-81. PMID: 19415899
7. Conformational dependence of integrin-binding peptides derived from homologous loop regions in the laminin α chains.  |  Ishikawa, M., et al. 2020. J Pept Sci. 26: e3284. PMID: 32885553
8. The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.  |  Miner, JH., et al. 1997. J Cell Biol. 137: 685-701. PMID: 9151674
9. Differential expression of laminin alpha chains during murine tooth development.  |  Salmivirta, K., et al. 1997. Dev Dyn. 210: 206-15. PMID: 9389447
10. Laminin alpha chains in developing tooth.  |  Salmivirta, K. and Ekblom, P. 1998. Ann N Y Acad Sci. 857: 279-82. PMID: 9917857

The preferred Laminin α-1 antibody is Laminin α-1 Antibody (G-12): sc-74418.