Lamin B2 Antibody (LN43): sc-56146
- Lamin B2 Antibody (LN43) is a mouse monoclonal IgG1, cited in 3 publications, provided at 50 µg/0.5 ml
- raised against the detergent insoluble fraction of PtK1 kidney cell line of kangaroo rat origin
- recommended for detection of an epitope located in the C-terminal part of Lamin B2 of mouse, rat, human and Xenopus origin by WB, IP, IF and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Lamin B2 Antibody (LN43). This work is in progress.
Lamin B2 Antibody (LN43) is a mouse monoclonal IgG1 antibody that detects Lamin B2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Lamin B2 plays a crucial role in maintaining the structural integrity of the nuclear envelope, which is essential for proper cellular function and longevity. As a key component of the nuclear lamina, Lamin B2 provides a supportive framework that helps preserve nuclear shape and facilitates interactions with chromatin, influencing gene expression and DNA replication. Lamin B2 localization within the nucleus ensures nuclear envelope integrity during cellular processes such as division and apoptosis. Notably, Lamin B2 undergoes post-translational modifications, including farnesylation and phosphorylation, which are critical for function and stability. Increased phosphorylation of Lamin B2 has been observed prior to nuclear envelope disintegration, suggesting these modifications may regulate interactions within the nuclear structure. Anti-Lamin B2 antibody (LN43) serves as an invaluable tool for researchers studying nuclear architecture dynamics and mechanisms of apoptosis, providing insights into processes that govern cell health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lamin B2 Antibody (LN43) | sc-56146 | 50 µg/0.5 ml | $322.00 |