Lamin B1 Antibody (G-1): sc-373918
- Lamin B1 Antibody (G-1) is a mouse monoclonal IgG3 κ, cited in 16 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 559-586 at the C-terminus of Lamin B1 of mouse origin
- recommended for detection of Lamin B1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See Lamin B1 (A-11): sc-377000 for Lamin B1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Lamin B1 Antibody (G-1) for WB and IHC(P) applications. This reagent is now offered in a bundle with Lamin B1 Antibody (G-1) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Lamin B1 Antibody (G-1) is a mouse monoclonal IgG3 antibody that detects Lamin B1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Lamin B1 plays a crucial role in maintaining the structural integrity of the nuclear envelope, which is essential for proper cellular function and longevity. As a key component of the nuclear lamina, Lamin B1 provides a scaffold that supports the nuclear envelope and interacts with chromatin, thereby influencing gene expression and cellular organization. Lamin B1′s localization within the nucleus is vital, as this protein helps to regulate nuclear shape and stability, and any disruption in Lamin B1 function can lead to significant cellular consequences, including apoptosis. Lamin B1 undergoes post-translational modifications, such as farnesylation and phosphorylation, which are critical for function and stability. Notably, increased phosphorylation of Lamin B1 occurs prior to nuclear envelope disintegration during apoptosis, suggesting these modifications play a regulatory role in protein interactions and associations. anti-Lamin B1 antibody (G-1) serves as an invaluable tool for researchers studying the dynamics of nuclear structure and mechanisms of apoptosis, providing insights into cellular processes that govern health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lamin B1 Antibody (G-1) | sc-373918 | 200 µg/ml | $322.00 | |||
Lamin B1 Antibody (G-1): m-IgGκ BP-HRP Bundle | sc-522556 | 200 µg Ab, 40 µg BP | $361.00 | |||
Lamin B1 (G-1) Neutralizing Peptide | sc-373918 P | 100 µg/0.5 ml | $69.00 |