LAIR-1 Antibody (14): sc-135966

LAIR-1 Antibody (14) is a mouse monoclonal IgG1 antibody that detects leukocyte-associated Ig-like receptor-1 (LAIR-1) in human samples through western blotting (WB) and immunoprecipitation (IP) applications. LAIR-1 is a transmembrane glycoprotein predominantly expressed on human peripheral blood mononuclear leukocytes, playing a crucial role in immune regulation. LAIR-1 is located on the cell surface, where LAIR-1 functions as an inhibitory receptor that modulates immune responses by recruiting SHP-1, a phosphatase that negatively regulates cell signaling pathways. LAIR-1′s location enables influence over the activation and proliferation of immune cells, such as T lymphocytes and natural killer (NK) cells. When LAIR-1 is engaged, LAIR-1 can inhibit NK cell-mediated cytotoxicity and promote programmed cell death in myelomonocytic leukemic cell lines, highlighting LAIR-1′s role in maintaining immune homeostasis and preventing excessive immune activation. Additionally, LAIR-1 undergoes phosphorylation at specific tyrosine residues, which is essential for LAIR-1′s function and interaction with SHP-1, and the involvement of Src family kinases in this process underscores the complexity of the signaling mechanisms at play. With significant implications in immune regulation, anti-LAIR-1 antibody (14) serves as an invaluable tool for researchers studying immune responses and potential therapeutic targets in hematological malignancies.

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LAIR-1 Antibody (14) References:

1. LAIR-1, a widely distributed human ITIM-bearing receptor on hematopoietic cells.  |  Meyaard, L. 1999. Curr Top Microbiol Immunol. 244: 151-7. PMID: 10453657
2. Enhanced secretion of leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) and soluble LAIR-1 in rheumatoid arthritis: LAIR-2 is a more efficient antagonist of the LAIR-1-collagen inhibitory interaction than is soluble LAIR-1.  |  Olde Nordkamp, MJ., et al. 2011. Arthritis Rheum. 63: 3749-57. PMID: 22127695
3. Clinicopathologic significance of LAIR-1 expression in hepatocellular carcinoma.  |  Wu, X., et al. 2019. Curr Probl Cancer. 43: 18-26. PMID: 29776595
4. LAIR-1 activation inhibits inflammatory macrophage phenotype in vitro.  |  Jin, J., et al. 2018. Cell Immunol. 331: 78-84. PMID: 29887420
5. Expression of LAIR-1 (CD305) on Human Blood Monocytes as a Marker of Hepatic Cirrhosis Progression.  |  Martínez-Esparza, M., et al. 2019. J Immunol Res. 2019: 2974753. PMID: 31019980
6. LAIR-1 suppresses cell growth of ovarian cancer cell via the PI3K-AKT-mTOR pathway.  |  Liu, Y., et al. 2020. Aging (Albany NY). 12: 16142-16154. PMID: 32628130
7. A perspective on LILRBs and LAIR1 as immune checkpoint targets for cancer treatment.  |  Zhang, CC. 2022. Biochem Biophys Res Commun. 633: 64-67. PMID: 36344166
8. LAIR1 drives glioma progression by nuclear focal adhesion kinase dependent expressions of cyclin D1 and immunosuppressive chemokines/cytokines.  |  Wei, X., et al. 2023. Cell Death Dis. 14: 684. PMID: 37845206
9. Cancer-associated fibroblast-secreted collagen is associated with immune inhibitor receptor LAIR1 in gliomas.  |  Tripathi, S., et al. 2024. J Clin Invest. 134: PMID: 38357919
10. LAIR1 promotes hepatocellular carcinoma cell metastasis and induces M2-macrophage infiltration through activating AKT-IKKβ-p65 axis.  |  Pan, B., et al. 2024. Mol Carcinog. 63: 1827-1841. PMID: 39016636

The preferred LAIR-1 antibody is LAIR-1 Antibody (F-5): sc-398141.