lactoferrin Antibody (a-bC-lobe): sc-52694
- lactoferrin Antibody (a-bC-lobe) is a mouse monoclonal IgG1, cited in 3 publications, provided at 100 µg/ml
- raised against amino acids 467-473 of lactoferrin of bovine origin
- recommended for detection of lactoferrin of human and bovine origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for lactoferrin Antibody (a-bC-lobe). This work is in progress.
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Lactoferrin Antibody (a-bC-lobe) is a mouse monoclonal IgG1 antibody that detects lactoferrin in human and bovine samples through applications such as western blotting (WB) and immunoprecipitation (IP). Lactoferrin plays a crucial role in iron metabolism by binding to iron and regulating its availability, which is essential for various biological processes, including cellular respiration and DNA synthesis. Lactoferrin is predominantly found in milk, tears, and leukocytes, where lactoferrin not only serves as an iron transporter but also exhibits antimicrobial properties, enhancing the immune response. Lactoferrin′s ability to degrade the IgA1 protease secreted by Haemophilus influenzae is particularly significant, as lactoferrin allows human IgA1 antibody to effectively prevent colonization by this pathogen. Additionally, lactoferrin has been shown to inhibit HIV-1 replication at the level of viral fusion and entry into cells, highlighting lactoferrin′s potential therapeutic applications in viral infections. The gene encoding human lactoferrin is located on chromosome 3p21.31, and lactoferrin expression is tightly regulated, reflecting lactoferrin′s importance in maintaining iron homeostasis and immune function. Anti-lactoferrin antibody (a-bC-lobe) is an invaluable tool for researchers studying the multifaceted roles of lactoferrin in health and disease.
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lactoferrin Antibody (a-bC-lobe) References:
- Lactoferrin and its biological functions. | Kanyshkova, TG., et al. 2001. Biochemistry (Mosc). 66: 1-7. PMID: 11240386
- Antiinflammatory activities of lactoferrin. | Conneely, OM. 2001. J Am Coll Nutr. 20: 389S-395S; discussion 396S-397S. PMID: 11603648
- Lactoferrin as an effector molecule in the skeleton. | Cornish, J. and Naot, D. 2010. Biometals. 23: 425-30. PMID: 20232111
- Lactoferrin for prevention of common viral infections. | Wakabayashi, H., et al. 2014. J Infect Chemother. 20: 666-71. PMID: 25182867
- Potential lactoferrin activity against pathogenic viruses. | Redwan, EM., et al. 2014. C R Biol. 337: 581-95. PMID: 25282173
- Overview of Lactoferrin as a Natural Immune Modulator. | Legrand, D. 2016. J Pediatr. 173 Suppl: S10-5. PMID: 27234406
- Targeting bacterial transferrin and lactoferrin receptors for vaccines. | Schryvers, AB. 2022. Trends Microbiol. 30: 820-830. PMID: 35232609
- Lactoferrin: A Nutraceutical with Activity against Colorectal Cancer. | Ramírez-Rico, G., et al. 2022. Front Pharmacol. 13: 855852. PMID: 35264972
- Review, role of lactoferrin in preventing preterm delivery. | Otsuki, K., et al. 2023. Biometals. 36: 521-530. PMID: 36495415
- Lactoferrin and the inflammatory response. | Baynes, RD. and Bezwoda, WR. 1994. Adv Exp Med Biol. 357: 133-41. PMID: 7762425
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
lactoferrin Antibody (a-bC-lobe) | sc-52694 | 100 µg/ml | $322.00 |