La Crosse Virus G1/G2 Antibody (10G5.4): sc-57891
- La Crosse Virus G1/G2 Antibody (10G5.4) is a mouse monoclonal IgG2a κ La Crosse Virus G1/G2 antibody provided at 200 µg/ml
- raised against La Crosse Virus grown on E6 Vero cells
- La Crosse Virus G1/G2 Antibody (10G5.4) is recommended for detection of La Crosse Virus by WB, IP and IF
- Anti-La Crosse Virus G1/G2 Antibody (10G5.4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for La Crosse Virus G1/G2 Antibody (10G5.4) for WB applications. These reagents are now offered in bundles with La Crosse Virus G1/G2 Antibody (10G5.4) (see ordering information below).
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La Crosse Virus G1/G2 Antibody (10G5.4) is a mouse monoclonal IgG2a kappa light chain antibody that detects the La Crosse Virus G1/G2 protein of La Crosse Virus origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). La Crosse Virus G1/G2 (10G5.4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The La Crosse Virus is a significant arbovirus, specifically classified as a Bunyavirus, responsible for La Crosse encephalitis, a disease that poses serious health risks, particularly to children. The G1 and G2 proteins play crucial roles in the virus′s ability to infect host cells and evade the immune response, as these proteins are involved in the formation of the viral envelope and the fusion process necessary for viral entry. Understanding the structure and function of these glycoproteins is vital for developing effective vaccines and therapeutic strategies against La Crosse Virus, especially given the potential for severe neurological complications in infected individuals. The virus is transmitted through the bite of infected Aedes triseriatus mosquitoes, which thrive in deciduous forest habitats, and can persist through winter in mosquito eggs, leading to seasonal outbreaks. Symptoms of La Crosse encephalitis can range from mild, such as nausea and headache, to severe, including seizures and permanent brain damage, underscoring the importance of research and diagnostic tools like La Crosse Virus G1/G2 (10G5.4) monoclonal antibody in combating this public health threat.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
La Crosse Virus G1/G2 Antibody (10G5.4) References:
- DNA-based vaccine against La Crosse virus: protective immune response mediated by neutralizing antibodies and CD4+ T cells. | Schuh, T., et al. 1999. Hum Gene Ther. 10: 1649-58. PMID: 10428210
- DNA vaccination against La Crosse virus. | Pavlovic, J., et al. 2000. Intervirology. 43: 312-21. PMID: 11251387
- Functional L polymerase of La Crosse virus allows in vivo reconstitution of recombinant nucleocapsids. | Blakqori, G., et al. 2003. J Gen Virol. 84: 1207-1214. PMID: 12692286
- Quantitative trait loci conditioning transovarial transmission of La Crosse virus in the eastern treehole mosquito, Ochlerotatus triseriatus. | Graham, DH., et al. 2003. Insect Mol Biol. 12: 307-18. PMID: 12864911
- La Crosse virus nonstructural protein NSs counteracts the effects of short interfering RNA. | Soldan, SS., et al. 2005. J Virol. 79: 234-44. PMID: 15596819
- Quantitative analysis of La Crosse virus transcription and replication in cell cultures and mosquitoes. | Kempf, BJ., et al. 2006. Am J Trop Med Hyg. 74: 224-32. PMID: 16474075
- A G1 glycoprotein epitope of La Crosse virus: a determinant of infection of Aedes triseriatus. | Sundin, DR., et al. 1987. Science. 235: 591-3. PMID: 3810159
- Pseudotype formation with La Crosse virus glycoproteins. | Bupp, K. and González-Scarano, F. 1998. J Gen Virol. 79 (Pt 4): 667-71. PMID: 9568959
- Short report: Diapause, transovarial transmission, and filial infection rates in geographic strains of La Crosse virus-infected Aedes triseriatus. | Woodring, J., et al. 1998. Am J Trop Med Hyg. 58: 587-8. PMID: 9598445
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
La Crosse Virus G1/G2 Antibody (10G5.4) | sc-57891 | 200 µg/ml | $316.00 | |||
La Crosse Virus G1/G2 Antibody (10G5.4): m-IgG Fc BP-HRP Bundle | sc-525669 | 200 µg Ab; 10 µg BP | $354.00 | |||
La Crosse Virus G1/G2 Antibody (10G5.4): m-IgG2a BP-HRP Bundle | sc-546359 | 200 µg Ab; 10 µg BP | $354.00 | |||
La Crosse Virus G1/G2 Antibody (10G5.4) AC | sc-57891 AC | 500 µg/ml, 25% agarose | $416.00 | |||
La Crosse Virus G1/G2 Antibody (10G5.4) HRP | sc-57891 HRP | 200 µg/ml | $316.00 | |||
La Crosse Virus G1/G2 Antibody (10G5.4) FITC | sc-57891 FITC | 200 µg/ml | $330.00 | |||
La Crosse Virus G1/G2 Antibody (10G5.4) PE | sc-57891 PE | 200 µg/ml | $343.00 | |||
La Crosse Virus G1/G2 Antibody (10G5.4) Alexa Fluor® 488 | sc-57891 AF488 | 200 µg/ml | $357.00 | |||
La Crosse Virus G1/G2 Antibody (10G5.4) Alexa Fluor® 546 | sc-57891 AF546 | 200 µg/ml | $357.00 | |||
La Crosse Virus G1/G2 Antibody (10G5.4) Alexa Fluor® 594 | sc-57891 AF594 | 200 µg/ml | $357.00 | |||
La Crosse Virus G1/G2 Antibody (10G5.4) Alexa Fluor® 647 | sc-57891 AF647 | 200 µg/ml | $357.00 | |||
La Crosse Virus G1/G2 Antibody (10G5.4) Alexa Fluor® 680 | sc-57891 AF680 | 200 µg/ml | $357.00 | |||
La Crosse Virus G1/G2 Antibody (10G5.4) Alexa Fluor® 790 | sc-57891 AF790 | 200 µg/ml | $357.00 |