L-type Ca++ CP γ3 Antibody (A-07): sc-81889
- L-type Ca++ CP γ3 Antibody (A-07) is a mouse monoclonal IgG1 κ L-type Ca++ CP γ3 antibody provided at 100 µg/ml
- raised against recombinant L-type Ca++ CP γ3 of human origin
- recommended for detection of L-type Ca++ CP γ3 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for L-type Ca++ CP γ3 Antibody (A-07). This work is in progress.
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L-type Ca++ CP γ3 Antibody (A-07) is a mouse monoclonal IgG1 kappa light chain antibody that detects L-type Ca++ CP gamma 3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-L-type Ca++ CP gamma 3 antibody (A-07) is available as a non-conjugated format. L-type Ca++ CP gamma 3 protein, also known as CACNG3 or Cacng2, is a crucial component of voltage-dependent calcium channels, which play a vital role in neurotransmitter release in neurons. L-type Ca++ CP gamma 3 is a 315 amino acid multi-pass membrane protein that belongs to the CACNG family and is one of eight gamma subunits modulating calcium current properties. L-type Ca++ CP gamma 3 stabilizes calcium current when the calcium channel is in a closed (inactivated) state, which is essential for maintaining proper neuronal signaling and preventing excitotoxicity. Defects in the gene encoding L-type Ca++ CP gamma 3 have been linked to familial infantile convulsive disorder with paroxysmal choreoathetosis, an autosomal dominant neurological disorder that underscores this protein′s importance in normal brain function. Using L-type Ca++ CP γ3 (A-07) monoclonal antibody can provide valuable insights into calcium signaling mechanisms and their implications in neurological disorders.
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L-type Ca++ CP γ3 Antibody (A-07) References:
- Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications. | Black, JL. and Lennon, VA. 1999. Mayo Clin Proc. 74: 357-61. PMID: 10221464
- Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication. | Burgess, DL., et al. 1999. Genome Res. 9: 1204-13. PMID: 10613843
- A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. | Burgess, DL., et al. 2001. Genomics. 71: 339-50. PMID: 11170751
- Human neuronal stargazin-like proteins, gamma2, gamma3 and gamma4; an investigation of their specific localization in human brain and their influence on CaV2.1 voltage-dependent calcium channels expressed in Xenopus oocytes. | Moss, FJ., et al. 2003. BMC Neurosci. 4: 23. PMID: 14505496
- Linkage and association analysis of CACNG3 in childhood absence epilepsy. | Everett, KV., et al. 2007. Eur J Hum Genet. 15: 463-72. PMID: 17264864
- Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location. | Powers, PA., et al. 1993. J Biol Chem. 268: 9275-9. PMID: 8387489
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-type Ca++ CP γ3 Antibody (A-07) | sc-81889 | 100 µg/ml | $333.00 |