L-type Ca++ CP γ2 Antibody (D-7): sc-376281
- L-type Ca++ CP γ2 Antibody (D-7) is a mouse monoclonal IgG1 κ L-type Ca++ CP γ2 antibody provided at 200 µg/ml
- raised against amino acids 244-323 mapping at the C-terminus of L-type Ca++ CP γ2 of human origin
- L-type Ca++ CP gamma 2 Antibody (D-7) is recommended for detection of L-type Ca++ CP γ2 of human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and bovine
- Anti-L-type Ca++ CP gamma 2 Antibody (D-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for L-type Ca++ CP γ2 Antibody (D-7) for WB applications. This reagent is now offered in a bundle with L-type Ca++ CP γ2 Antibody (D-7) (see ordering information below).
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L-type Ca++ CP γ2 Antibody (D-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects L-type Ca++ CP gamma 2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). L-type Ca++ CP γ2 (D-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. L-type Ca++ CP gamma 2, also known as stargazin, plays a crucial role in the regulation of synaptic transmission by modulating the trafficking of AMPA receptors to the synaptic membrane, which is essential for proper neuronal communication and plasticity. L-type Ca++ CP gamma 2 is predominantly located in the synaptic plasma membranes of excitatory neurons, where L-type Ca++ CP gamma 2 facilitates the assembly of receptor complexes and enhances synaptic strength, thereby influencing learning and memory processes. The interaction of L-type Ca++ CP gamma 2 with other subunits of calcium channels, such as gamma3 and gamma4, further underscores its importance in the formation of macromolecular signaling complexes that fine-tune calcium signaling pathways in response to synaptic activity. Anti-L-type Ca++ CP γ2 antibody (D-7) enables researchers to gain valuable insights into the mechanisms of synaptic regulation and the role of calcium channels in various physiological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
L-type Ca++ CP γ2 Antibody (D-7) References:
- Structure and regulation of voltage-gated Ca2+ channels. | Catterall, WA. 2000. Annu Rev Cell Dev Biol. 16: 521-55. PMID: 11031246
- Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. | Chen, L., et al. Nature. 408: 936-43. PMID: 11140673
- A beta2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2. | Davare, MA., et al. 2001. Science. 293: 98-101. PMID: 11441182
- Molecular biology of calcium channels. | Perez-Reyes, E. and Schneider, T. 1995. Kidney Int. 48: 1111-24. PMID: 8569073
- The molecular basis of voltage-gated Ca2+ channel diversity: is it time for T? | Randall, AD. 1998. J Membr Biol. 161: 207-13. PMID: 9493126
- The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit. | Letts, VA., et al. 1998. Nat Genet. 19: 340-7. PMID: 9697694
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-type Ca++ CP γ2 Antibody (D-7) | sc-376281 | 200 µg/ml | $316.00 | |||
L-type Ca++ CP γ2 Antibody (D-7): m-IgG Fc BP-HRP Bundle | sc-526019 | 200 µg Ab; 10 µg BP | $354.00 | |||
L-type Ca++ CP γ2 Antibody (D-7) AC | sc-376281 AC | 500 µg/ml, 25% agarose | $416.00 | |||
L-type Ca++ CP γ2 Antibody (D-7) HRP | sc-376281 HRP | 200 µg/ml | $316.00 | |||
L-type Ca++ CP γ2 Antibody (D-7) FITC | sc-376281 FITC | 200 µg/ml | $330.00 | |||
L-type Ca++ CP γ2 Antibody (D-7) PE | sc-376281 PE | 200 µg/ml | $343.00 | |||
L-type Ca++ CP γ2 Antibody (D-7) Alexa Fluor® 488 | sc-376281 AF488 | 200 µg/ml | $357.00 | |||
L-type Ca++ CP γ2 Antibody (D-7) Alexa Fluor® 546 | sc-376281 AF546 | 200 µg/ml | $357.00 | |||
L-type Ca++ CP γ2 Antibody (D-7) Alexa Fluor® 594 | sc-376281 AF594 | 200 µg/ml | $357.00 | |||
L-type Ca++ CP γ2 Antibody (D-7) Alexa Fluor® 647 | sc-376281 AF647 | 200 µg/ml | $357.00 | |||
L-type Ca++ CP γ2 Antibody (D-7) Alexa Fluor® 680 | sc-376281 AF680 | 200 µg/ml | $357.00 | |||
L-type Ca++ CP γ2 Antibody (D-7) Alexa Fluor® 790 | sc-376281 AF790 | 200 µg/ml | $357.00 |