L-type Ca++ CP β4 Antibody (H-7): sc-376432
- L-type Ca++ CP β4 Antibody (H-7) is a mouse monoclonal IgG2a κ L-type Ca++ CP β4 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 425-463 near the C-terminus of L-type Ca++ CP β4 of human origin
- L-type Ca++ CP beta 4 Antibody (H-7) is recommended for detection of L-type Ca++ CP β4 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-L-type Ca++ CP beta 4 Antibody (H-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for L-type Ca++ CP β4 Antibody (H-7) for WB applications. These reagents are now offered in bundles with L-type Ca++ CP β4 Antibody (H-7) (see ordering information below).
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L-type Ca++ CP β4 Antibody (H-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects L-type Ca++ CP beta 4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-L-type Ca++ CP β4 antibody (H-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. L-type Ca++ CP beta 4 protein, also known as CACNB4, plays a crucial role in voltage-dependent calcium channels′ function, essential for neurotransmitter release in neurons. CACNB4 is primarily located in the cytoplasm and regulates G protein inhibition, current amplitude, and voltage dependence of activation and inactivation of calcium channels. β4 subunit shows highest expression in the cerebellum and contributes to calcium current diversity, as well as membrane trafficking of α1 subunit. A splice variant of CACNB4 enhances cellular excitability, significant for neuronal signaling. Mutations in CACNB4 have been linked to idiopathic generalized epilepsy and juvenile myoclonic epilepsy, highlighting CACNB4′s importance in neurological health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
L-type Ca++ CP β4 Antibody (H-7) References:
- Coding and noncoding variation of the human calcium-channel beta4-subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia. | Escayg, A., et al. 2000. Am J Hum Genet. 66: 1531-9. PMID: 10762541
- Differential expression of alpha 1 and beta subunits of voltage dependent Ca2+ channel at the neuromuscular junction of normal and P/Q Ca2+ channel knockout mouse. | Pagani, R., et al. 2004. Neuroscience. 123: 75-85. PMID: 14667443
- Expression pattern of voltage-dependent calcium channel alpha1 and beta subunits in adrenal gland of N-type Ca2+ channel alpha1B subunit gene-deficient mice. | Takahashi, E. and Nagasu, T. 2005. Mol Cell Biochem. 271: 91-9. PMID: 15881659
- Solution structure of the N-terminal A domain of the human voltage-gated Ca2+channel beta4a subunit. | Vendel, AC., et al. 2006. Protein Sci. 15: 378-83. PMID: 16385006
- Vascular calcium channels and high blood pressure: pathophysiology and therapeutic implications. | Sonkusare, S., et al. 2006. Vascul Pharmacol. 44: 131-42. PMID: 16427812
- Mutations in the GABRA1 and EFHC1 genes are rare in familial juvenile myoclonic epilepsy. | Ma, S., et al. 2006. Epilepsy Res. 71: 129-34. PMID: 16839746
- Mutation analyses of genes on 6p12-p11 in patients with juvenile myoclonic epilepsy. | Suzuki, T., et al. 2006. Neurosci Lett. 405: 126-31. PMID: 16876319
- Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer's disease. | Heinzen, EL., et al. 2007. Genome Biol. 8: R32. PMID: 17343748
- A beta 4 isoform-specific interaction site in the carboxyl-terminal region of the voltage-dependent Ca2+ channel alpha 1A subunit. | Walker, D., et al. 1998. J Biol Chem. 273: 2361-7. PMID: 9442082
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-type Ca++ CP β4 Antibody (H-7) | sc-376432 | 200 µg/ml | $316.00 | |||
L-type Ca++ CP β4 Antibody (H-7): m-IgG Fc BP-HRP Bundle | sc-526030 | 200 µg Ab; 10 µg BP | $354.00 | |||
L-type Ca++ CP β4 Antibody (H-7): m-IgG2a BP-HRP Bundle | sc-546487 | 200 µg Ab; 10 µg BP | $354.00 | |||
L-type Ca++ CP β4 Antibody (H-7) AC | sc-376432 AC | 500 µg/ml, 25% agarose | $416.00 | |||
L-type Ca++ CP β4 Antibody (H-7) HRP | sc-376432 HRP | 200 µg/ml | $316.00 | |||
L-type Ca++ CP β4 Antibody (H-7) FITC | sc-376432 FITC | 200 µg/ml | $330.00 | |||
L-type Ca++ CP β4 Antibody (H-7) PE | sc-376432 PE | 200 µg/ml | $343.00 | |||
L-type Ca++ CP β4 Antibody (H-7) Alexa Fluor® 488 | sc-376432 AF488 | 200 µg/ml | $357.00 | |||
L-type Ca++ CP β4 Antibody (H-7) Alexa Fluor® 546 | sc-376432 AF546 | 200 µg/ml | $357.00 | |||
L-type Ca++ CP β4 Antibody (H-7) Alexa Fluor® 594 | sc-376432 AF594 | 200 µg/ml | $357.00 | |||
L-type Ca++ CP β4 Antibody (H-7) Alexa Fluor® 647 | sc-376432 AF647 | 200 µg/ml | $357.00 | |||
L-type Ca++ CP β4 Antibody (H-7) Alexa Fluor® 680 | sc-376432 AF680 | 200 µg/ml | $357.00 | |||
L-type Ca++ CP β4 Antibody (H-7) Alexa Fluor® 790 | sc-376432 AF790 | 200 µg/ml | $357.00 | |||
L-type Ca++ CP β4 (H-7) Neutralizing Peptide | sc-376432 P | 100 µg/0.5 ml | $68.00 |