Molecular structure of L-755,507, CAS Number: 159182-43-1
L-755,507 (CAS 159182-43-1)
See product citations (2)
Alternate Names:
L-755,507 is also known as a selective β3-adrenergic receptor partial agonist.
Application:
L-755,507 is a very potent, selective β3-adrenergic receptor partial agonist and enhancer of CRISPR-mediated HDR efficiency.
CAS Number:
159182-43-1
Purity:
≥97%
Molecular Weight:
584.73
Molecular Formula:
C30H40N4O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-755,507 is a compound that is utilized in research focused on the beta-3 adrenergic receptor. This receptor subtype is of interest due to its involvement in the regulation of energy expenditure and thermogenesis, primarily in adipose tissue. L-755,507 acts as an agonist at this receptor, and studies involving this compound aim to elucidate the signaling pathways and physiological outcomes of beta-3 adrenergic activation. In metabolic studies, L-755,507 is used to assess the potential for increasing metabolic rate and lipolysis. It also serves as a tool in the field of endocrinology to understand the mechanisms that might influence insulin sensitivity and glucose uptake. Research with L-755,507 aids in the exploration of metabolic conditions and contributes to the identification of targets for potential alterations in metabolic regulation.
L-755,507 (CAS 159182-43-1) References
- Human beta3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides. | Parmee, ER., et al. 1999. Bioorg Med Chem Lett. 9: 749-54. PMID: 10201841
- Mutated human beta3-adrenergic receptor (Trp64Arg) lowers the response to beta3-adrenergic agonists in transfected 3T3-L1 preadipocytes. | Kimura, K., et al. 2000. Horm Metab Res. 32: 91-6. PMID: 10786926
- Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice. | Kohout, TA., et al. 2001. Circulation. 104: 2485-91. PMID: 11705829
- The beta3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor. | Sato, M., et al. 2008. Mol Pharmacol. 74: 1417-28. PMID: 18684840
- Do β3-adrenergic receptors play a role in guinea pig detrusor smooth muscle excitability and contractility? | Afeli, SA., et al. 2012. Am J Physiol Renal Physiol. 302: F251-63. PMID: 21993887
- The favorable kinetics and balance of nebivolol-stimulated nitric oxide and peroxynitrite release in human endothelial cells. | Mason, RP., et al. 2013. BMC Pharmacol Toxicol. 14: 48. PMID: 24074014
- Small molecules enhance CRISPR genome editing in pluripotent stem cells. | Yu, C., et al. 2015. Cell Stem Cell. 16: 142-7. PMID: 25658371
- Programmable DNA repair with CRISPRa/i enhanced homology-directed repair efficiency with a single Cas9. | Ye, L., et al. 2018. Cell Discov. 4: 46. PMID: 30062046
- A novel inhibitor L755507 efficiently blocks c-Myc-MAX heterodimerization and induces apoptosis in cancer cells. | Singh, A., et al. 2021. J Biol Chem. 297: 100903. PMID: 34157284
- Modification of improved-genome editing via oviductal nucleic acids delivery (i-GONAD)-mediated knock-in in rats. | Aoshima, T., et al. 2021. BMC Biotechnol. 21: 63. PMID: 34724929
- An effective double gene knock-in strategy using small-molecule L755507 in the medaka fish (Oryzias latipes). | Murakami, Y. and Kobayashi, T. 2022. Genesis. 60: e23465. PMID: 35072325
- A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. | Fisher, MH., et al. 1998. J Clin Invest. 101: 2387-93. PMID: 9616210
- Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist. | Parmee, ER., et al. 1998. Bioorg Med Chem Lett. 8: 1107-12. PMID: 9871717
- 3-Pyridylethanolamines: potent and selective human beta 3 adrenergic receptor agonists. | Naylor, EM., et al. 1998. Bioorg Med Chem Lett. 8: 3087-92. PMID: 9873681
- Trp64Arg mutation of beta3-adrenoceptor gene deteriorates lipolysis induced by beta3-adrenoceptor agonist in human omental adipocytes. | Umekawa, T., et al. 1999. Diabetes. 48: 117-20. PMID: 9892231
Activator of:
beta3-AR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-755,507, 10 mg | sc-204045 | 10 mg | $336.00 | |||
L-755,507, 50 mg | sc-204045A | 50 mg | $877.00 |