CRISPR Support Support Products
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Blasticidin S HCl solution | 3513-03-9 | sc-495389 sc-495389B sc-495389A | 1 ml 100 ml 10 x 1 ml | $43.00 $3569.00 $411.00 | 13 | |
Blasticidin S HCl solution is a potent selection agent that operates through unique interactions with ribosomal RNA, inhibiting protein synthesis in sensitive organisms. Its mechanism involves binding to the ribosomal A-site, disrupting peptide bond formation and halting translation. This specificity allows for effective selection in CRISPR applications, ensuring only successfully edited cells survive. The compound's stability in solution and ability to target diverse cell types enhance its utility in genetic engineering workflows. | ||||||
Hygromycin B solution | 31282-04-9 | sc-29067 | 1 g | $104.00 | 40 | |
Hygromycin B solution is a selective agent that disrupts protein synthesis by binding to the ribosomal RNA, specifically targeting the ribosomal A-site. This interaction inhibits translation by preventing the incorporation of aminoacyl-tRNA, leading to the cessation of protein production in susceptible organisms. Its unique mechanism of action allows for effective selection in CRISPR applications, ensuring that only genetically modified cells thrive. The compound's solubility and stability further enhance its role in genetic manipulation. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $42.00 $214.00 $832.00 $66.00 | 394 | |
Puromycin dihydrochloride acts as a potent inhibitor of protein synthesis by mimicking aminoacyl-tRNA, facilitating premature termination of polypeptide chains during translation. This unique mechanism allows it to effectively disrupt ribosomal function, making it a valuable tool in CRISPR applications. Its rapid kinetics and ability to induce cell death in non-modified cells ensure a robust selection process, promoting the survival of genetically edited organisms. | ||||||
L-755,507 | 159182-43-1 | sc-204045 sc-204045A | 10 mg 50 mg | $343.00 $895.00 | 2 | |
L-755,507 serves as a crucial enhancer in CRISPR applications by modulating gene expression through specific interactions with regulatory proteins. Its unique ability to stabilize RNA-protein complexes facilitates precise editing by promoting the recruitment of Cas9 to target sites. The compound exhibits distinct reaction kinetics, allowing for rapid cellular uptake and effective modulation of transcriptional pathways, thereby optimizing the efficiency of genome editing processes. | ||||||
Blasticidin S Hydrochloride | 3513-03-9 | sc-204655A sc-204655 | 25 mg 100 mg | $367.00 $520.00 | 20 | |
Blasticidin S Hydrochloride acts as a potent selection agent in CRISPR experiments, effectively inhibiting protein synthesis in eukaryotic cells. Its unique mechanism involves binding to the ribosomal subunit, disrupting translation and allowing for the identification of successfully edited cells. This selective pressure enhances the efficiency of gene editing by ensuring that only modified cells survive, thus streamlining the screening process for desired genetic alterations. | ||||||