Molecular structure of L-692,585, CAS Number: 145455-35-2
L-692,585 (CAS 145455-35-2)
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Application:
L-692,585 is a non-peptidyl GHS R1 acticvator
CAS Number:
145455-35-2
Purity:
≥99%
Molecular Weight:
567.69 (anhydrous)
Molecular Formula:
C32H37N7O3•xH2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-692,585 is a potent, non-peptidyl growth hormone (GH) secretagogue.
L-692,585 (CAS 145455-35-2) References
- Growth hormone (GH)-releasing hormone (GHRH) and the GH secretagogue (GHS), L692,585, differentially modulate rat pituitary GHS receptor and GHRH receptor messenger ribonucleic acid levels. | Kineman, RD., et al. 1999. Endocrinology. 140: 3581-6. PMID: 10433214
- Growth hormone secretagogue activation of the arcuate nucleus and brainstem occurs via a non-noradrenergic pathway. | Bailey, AR., et al. 2000. J Neuroendocrinol. 12: 191-7. PMID: 10718914
- Mechanism of action of the growth hormone secretagogue, L-692,585, on isolated porcine somatotropes. | Glavaski-Joksimovic, A., et al. 2002. J Endocrinol. 175: 625-36. PMID: 12475374
- Number of secretory vesicles in growth hormone cells of the pituitary remains unchanged after secretion. | Lee, JS., et al. 2004. Exp Biol Med (Maywood). 229: 632-9. PMID: 15229357
- Effects of ghrelin on growth hormone secretion in vivo in ruminants. | Hashizume, T., et al. 2005. Regul Pept. 126: 61-5. PMID: 15620415
- Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor. | Bennett, KA., et al. 2009. Mol Pharmacol. 76: 802-11. PMID: 19625579
- Intracerebroventricular and intravenous administration of growth hormone secretagogue L-692,585, somatostatin, neuropeptide Y and galanin in pig: dose-dependent effects on growth hormone secretion. | Cho, SJ., et al. 2010. Comp Biochem Physiol C Toxicol Pharmacol. 151: 412-9. PMID: 20074661
- Atractylodin Induces Myosin Light Chain Phosphorylation and Promotes Gastric Emptying through Ghrelin Receptor. | Bai, Y., et al. 2017. Evid Based Complement Alternat Med. 2017: 2186798. PMID: 28883883
- Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action. | Fairhall, KM., et al. 1995. J Endocrinol. 144: 555-60. PMID: 7738479
- Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl growth hormone secretagogue, on plasma growth hormone, IGF-1, ACTH, cortisol, prolactin, insulin, and thyroxine levels in beagles. | Jacks, T., et al. 1994. J Endocrinol. 143: 399-406. PMID: 7830002
- Identification of a new G-protein-linked receptor for growth hormone secretagogues. | Pong, SS., et al. 1996. Mol Endocrinol. 10: 57-61. PMID: 8838145
- MK-0677, a potent, novel, orally active growth hormone (GH) secretagogue: GH, insulin-like growth factor I, and other hormonal responses in beagles. | Jacks, T., et al. 1996. Endocrinology. 137: 5284-9. PMID: 8940347
- Inhibition of L-692,429-stimulated rat growth hormone release by a weak substance P antagonist: L-756,867. | Cheng, K., et al. 1997. J Endocrinol. 152: 155-8. PMID: 9014851
- Peptidomimetic regulation of growth hormone secretion. | Smith, RG., et al. 1997. Endocr Rev. 18: 621-45. PMID: 9331545
- Structural requirements for the activation of the human growth hormone secretagogue receptor by peptide and nonpeptide secretagogues. | Feighner, SD., et al. 1998. Mol Endocrinol. 12: 137-45. PMID: 9440817
Inhibitor of:
Ghrelin.Activator of:
GHS-R1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-692,585, 10 mg | sc-204043 | 10 mg | $245.00 |