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KV1.3 Antibody (G-9) - Western Blotting - Image 386837
KV1.3 Antibody (G-9): sc-398855. Western blot analysis of KV1.3 expression in Jurkat whole cell lysate.
KV1.3 Antibody (G-9) - Western Blotting - Image 386837
KV1.3 Antibody (G-9): sc-398855. Western blot analysis of KV1.3 expression in Jurkat whole cell lysate.
KV1.3 Antibody (G-9) - Western Blotting - Image 309537
KV1.3 Antibody (G-9): sc-398855. Western blot analysis of KV1.3 expression in non-transfected 293T: sc-117752 (A), human KV1.3 transfected 293T: sc-159570 (B) and Jurkat (C) whole cell lysates.
KV1.3 Antibody (G-9): sc-398855. Western blot analysis of KV1.3 expression in Jurkat whole cell lysate.

KV1.3 Antibody (G-9): sc-398855

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Datasheets
  • KV1.3 Antibody (G-9) is a mouse monoclonal IgG3 KV1.3 antibody, cited in 2 publications, provided at 200 µg/ml
  • specific for an epitope mapping between amino acids 535-556 within a C-terminal cytoplasmic domain of KV1.3 of human origin
  • recommended for detection of KV1.3 of mouse, rat and human origin by WB, IP, IF and ELISA
  • m-IgG Fc BP-HRP is the preferred secondary detection reagent for KV1.3 Antibody (G-9) for WB applications. This reagent is now offered in a bundle with KV1.3 Antibody (G-9) (see ordering information below).
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KV1.3 Antibody (G-9) is a mouse monoclonal IgG3 antibody that detects KV1.3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-KV1.3 antibody (G-9) is available as the non-conjugated form. KV1.3 (G-9) antibody recognizes a protein crucial for regulating electrical activity in excitable cells, such as neurons and muscle cells, by contributing to action potential repolarization. KV1.3 (G-9) monoclonal antibody targets a channel within the voltage-gated potassium channel family, which forms tetrameric structures allowing diverse gating and permeation properties. Anti-KV1.3 antibody (G-9) helps study a protein essential for neuronal signaling that influences heart rhythm and neurotransmitter release. Understanding KV1.3 dynamics and interactions provides insights into potential therapeutic targets for epilepsy, cardiac arrhythmias, and other excitability disorders.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

KV1.3 Antibody (G-9) References:

  1. Subunit composition of Kv1 channels in human CNS.  |  Coleman, SK., et al. 1999. J Neurochem. 73: 849-58. PMID: 10428084
  2. Subunit composition determines Kv1 potassium channel surface expression.  |  Manganas, LN. and Trimmer, JS. 2000. J Biol Chem. 275: 29685-93. PMID: 10896669
  3. Kv1.3 channels facilitate the connection between metabolism and blood flow in the heart.  |  Ohanyan, V., et al. 2017. Microcirculation. 24: PMID: 28504408
  4. Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.  |  Sarkar, S., et al. 2020. J Clin Invest. 130: 4195-4212. PMID: 32597830
  5. Kv1.3 K+ Channel Physiology Assessed by Genetic and Pharmacological Modulation.  |  Varanita, T., et al. 2023. Physiology (Bethesda). 38: 0. PMID: 35998249
  6. Blockade of Kv1.3 Potassium Channel Inhibits Microglia-Mediated Neuroinflammation in Epilepsy.  |  Zhang, X., et al. 2022. Int J Mol Sci. 23: PMID: 36499018
  7. Kv1.3 in the spotlight for treating immune diseases.  |  Navarro-Pérez, M., et al. 2024. Expert Opin Ther Targets. 28: 67-82. PMID: 38316438
  8. KCNE4-dependent modulation of Kv1.3 pharmacology.  |  Sastre, D., et al. 2024. Biochem Pharmacol. 226: 116368. PMID: 38880360
  9. The brain Kv1.1 potassium channel: in vitro and in vivo studies on subunit assembly and posttranslational processing.  |  Deal, KK., et al. 1994. J Neurosci. 14: 1666-76. PMID: 8126562
  10. Immunohistochemical localization of five members of the Kv1 channel subunits: contrasting subcellular locations and neuron-specific co-localizations in rat brain.  |  Veh, RW., et al. 1995. Eur J Neurosci. 7: 2189-205. PMID: 8563969
  11. Beta subunits promote K+ channel surface expression through effects early in biosynthesis.  |  Shi, G., et al. 1996. Neuron. 16: 843-52. PMID: 8608002
  12. Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes.  |  Rhodes, KJ., et al. 1997. J Neurosci. 17: 8246-58. PMID: 9334400

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

KV1.3 Antibody (G-9)

sc-398855
200 µg/ml
$322.00

KV1.3 Antibody (G-9): m-IgG Fc BP-HRP Bundle

sc-526332
200 µg Ab; 10 µg BP
$361.00

KV1.3 (G-9) Neutralizing Peptide

sc-398855 P
100 µg/0.5 ml
$69.00

Thank you for your answer, but I see that you also have the two bands that I see in my WB. In your second reference image, you analyzed tree samples, A) HEK293 not transfected, B) HEK293T transfected with Kv1.3 (see two bands here) and C) Jurkat.

Asked by: Salvador72
Thanks for your question! Yes, you can sometimes see additional banding in transfected lysate tests due to incomplete products of translation. These are different than endogenous protein bands. Please reach out directly to your local distributor for further technical assistance if you wish to discuss your results.
Answered by: Tech Service
Date published: 2019-10-23

Hi, I used a free sample of Kv1.3 antibody (G-9). I does a assay diferent T cells models, but in each of these, two nearby bands appear. I would say that they would be approximately 55 and 60 KDa, do you know what these two bands could be due to?

Asked by: Salvador72
Thank you for your question. Unfortunately we do not have any information regarding the bands you are seeing as we have not seen them in house. I would suggest running a secondary control and optimize your conditions to see if you still see these extra bands.
Answered by: Tech Service
Date published: 2019-10-22

What application is the blocking peptide sc-398855 P appropriate for?

Asked by: cjMara
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Another good antibody recognizing a Kv memberThe kv1.3 antibody is an excellent antibody that I tested for western blot. Usually membrane proteins are tricky, they shift a lot in mass because of different post transnational modifications in tissue samples, The KCNA3/Kv1.3 gives a protein of 63kDa in human (theoretical, calculated by Expassy), in rat and mouse, the genomic regions harboring Kv1.3 is still not resolved and therefore, no transcripts yet, but it should be around the same mol weight as of human. In the blot picture (attached) you can clearly see a approximately 75kDa protein band which is Kv1.3 and then there is a higher molecular weight approximately 180 kDa band that is possibly the glycosylated form. It is interesting this the Kv1.3 band is less intense for another brain tissue (right panel) but the non-specific band is of comparable intensity (indicating same amount of proteins loaded for 2 tissues) suggesting that this gene is deferentially expressed in different parts of the rat brain. Also this is an indication of the specificity of the antibody. So, I will definitely recommend this antibody for your research.
Date published: 2017-04-10
Rated 5 out of 5 by from Produced positive Western blot data of KV1Produced positive Western blot data of KV1.3 expression in non-transfected 293T, human KV1.3 transfected 293T and Jurkat whole cell lysates. -SCBT QC
Date published: 2014-05-21
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KV1.3 Antibody (G-9) is rated 5.0 out of 5 by 2.
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