Molecular structure of KU14R, CAS Number: 189224-48-4
KU14R (CAS 189224-48-4)
See product citations (2)
Alternate Names:
2-(2-ethyl-2,3-dihydro-2-benzofuranyl)-2-imidazole
Application:
KU14R is a pancreatic β-cell I3 binding site antagonist
CAS Number:
189224-48-4
Molecular Weight:
214.27
Molecular Formula:
C13H14N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
KU14R is an antagonist of the pancreatic β-cell atypical imidazoline binding site (putative I3 receptor). KU14R has also been shown to selectively block efaroxan-induced insulin secretion.
KU14R (CAS 189224-48-4) References
- Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14r and RX801080. | Ball, AJ., et al. 2000. Pharmacol Res. 42: 575-9. PMID: 11058411
- Effects of the imidazoline ligands efaroxan and KU14R on blood glucose homeostasis in the mouse. | Mayer, G. and Taberner, PV. 2002. Eur J Pharmacol. 454: 95-102. PMID: 12409010
- Essential role of the imidazoline moiety in the insulinotropic effect but not the KATP channel-blocking effect of imidazolines; a comparison of the effects of efaroxan and its imidazole analogue, KU14R. | Bleck, C., et al. 2005. Diabetologia. 48: 2567-75. PMID: 16283242
- Activation of imidazoline-I3 receptors ameliorates pancreatic damage. | Li, Y., et al. 2015. Clin Exp Pharmacol Physiol. 42: 964-971. PMID: 26112210
- Allantoin ameliorates chemically-induced pancreatic β-cell damage through activation of the imidazoline I3 receptors. | Amitani, M., et al. 2015. PeerJ. 3: e1105. PMID: 26290782
- Identification of morin as an agonist of imidazoline I-3 receptor for insulin secretion in diabetic rats. | Lin, MH., et al. 2017. Naunyn Schmiedebergs Arch Pharmacol. 390: 997-1003. PMID: 28689255
- Investigation of morin-induced insulin secretion in cultured pancreatic cells. | Lin, MH., et al. 2017. Clin Exp Pharmacol Physiol. 44: 1254-1262. PMID: 28699234
- The Regulation Mechanism of MUC5AC Secretion in Airway of Obese Asthma. | Li, T., et al. 2022. Cell Mol Biol (Noisy-le-grand). 68: 153-159. PMID: 36495503
- The effect of the putative endogenous imidazoline receptor ligand, clonidine-displacing substance, on insulin secretion from rat and human islets of Langerhans. | Chan, SL., et al. 1997. Br J Pharmacol. 120: 926-32. PMID: 9138700
- Clotrimazole and efaroxan stimulate insulin secretion by different mechanisms in rat pancreatic islets. | Chan, SL., et al. 1997. Naunyn Schmiedebergs Arch Pharmacol. 356: 763-8. PMID: 9453462
Inhibitor of:
Enzyme, and Nischarin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KU14R, 10 mg | sc-204031 | 10 mg | $141.00 | |||
KU14R, 50 mg | sc-204031A | 50 mg | $599.00 |