Krs-1 Antibody (87.K): sc-130405

Krs-1 Antibody (87.K) is a mouse monoclonal IgG2a kappa light chain antibody that detects Krs-1 of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Krs-1 antibody (87.K) is available as the non-conjugated format. Krs-1, also known as MST-2, plays a crucial role in cellular signaling pathways, particularly in the regulation of apoptosis and cell proliferation. Krs-1 is a member of the mammalian Ste20-like kinases, which are part of the GCK subfamily of serine/threonine kinases. Krs-1 is primarily located in the cytoplasm and can translocate to the nucleus under certain conditions, which is significant for modulating various signaling cascades, including those activated by G protein-coupled receptors. Krs-1 phosphorylates specific substrates, including itself, allowing participation in the activation of downstream effectors such as ERK and JNK, which are vital for cellular responses to stress and growth signals. Additionally, Krs-1 is a direct substrate of caspase-3, linking to apoptotic pathways and highlighting importance in maintaining cellular homeostasis. The diverse roles of Krs-1 in these critical processes make this protein an essential target for research in cancer and other diseases where signaling pathways are disrupted.

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Krs-1 Antibody (87.K) References:

1. Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase.  |  Zhou, TH., et al. 2000. J Biol Chem. 275: 2513-9. PMID: 10644707
2. Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway.  |  Raitt, DC., et al. 2000. EMBO J. 19: 4623-31. PMID: 10970855
3. MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation.  |  Lee, KK., et al. 2001. J Biol Chem. 276: 19276-85. PMID: 11278283
4. MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway.  |  Lin, JL., et al. 2001. Oncogene. 20: 6559-69. PMID: 11641781
5. The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.  |  Leberer, E., et al. 1992. EMBO J. 11: 4815-24. PMID: 1464311
6. Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements.  |  Schinkmann, K. and Blenis, J. 1997. J Biol Chem. 272: 28695-703. PMID: 9353338

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Krs-1 Antibody (87.K) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Krs-1 Antibody (87.K) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Krs-1 Antibody (87.K) Specifications

Alternate Product Name: Krs-1

Product Clone Name: 87.K

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 253-350

Epitope Target: Krs-1

Epitope Species: human

Product Reactivity/Detection: Krs-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Krs-1 Antibody (87.K): N/A