KMCP1 Antibody (C-7): sc-398835
- KMCP1 Antibody (C-7) is a mouse monoclonal IgM κ KMCP1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 224-248 near the C-terminus of KMCP1 of human origin
- recommended for detection of KMCP1 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for KMCP1 Antibody (C-7). This work is in progress.
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KMCP1 Antibody (C-7) is a mouse monoclonal IgM kappa antibody that detects KMCP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KMCP1 Antibody (C-7) is available as the non-conjugated anti-KMCP1 antibody (C-7). The kidney mitochondrial carrier protein-1 (KMCP1), also known as solute carrier family 25 member 30 (SLC25A30), plays a crucial role in metabolite transport across the inner mitochondrial membrane, essential for maintaining cellular energy homeostasis. KMCP1 functions as a multi-pass membrane protein predominantly localized in mitochondria and shows high expression in kidney cortex, where KMCP1 supports increased mitochondrial metabolism, particularly during oxidative stress. KMCP1 shares close relation with brain mitochondrial carrier protein-1 (BMCP1), another multi-pass membrane protein primarily expressed in brain and testis. BMCP1 facilitates mitochondrial proton leak, influencing energy efficiency and thermogenesis, highlighting the importance of mitochondrial transport mechanisms in various tissues. KMCP1 up-regulation in response to oxidative damage suggests a role in cellular protection and metabolic adaptation, making KMCP1 a significant target for research in mitochondrial function and related disorders.
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KMCP1 Antibody (C-7) References:
- Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. | Yu, XX., et al. 2000. FASEB J. 14: 1611-8. PMID: 10928996
- BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production. | Kim-Han, JS., et al. 2001. J Neurochem. 79: 658-68. PMID: 11701769
- A new renal mitochondrial carrier, KMCP1, is up-regulated during tubular cell regeneration and induction of antioxidant enzymes. | Haguenauer, A., et al. 2005. J Biol Chem. 280: 22036-43. PMID: 15809292
- The mitochondrial carrier family of transport proteins: structural, functional, and evolutionary relationships. | Kuan, J. and Saier, MH. 1993. Crit Rev Biochem Mol Biol. 28: 209-33. PMID: 8325039
- Highly conserved charge-pair networks in the mitochondrial carrier family. | Nelson, DR., et al. 1998. J Mol Biol. 277: 285-308. PMID: 9514746
- BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. | Sanchis, D., et al. 1998. J Biol Chem. 273: 34611-5. PMID: 9852133
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KMCP1 Antibody (C-7) | sc-398835 | 200 µg/ml | $316.00 | |||
KMCP1 (C-7) Neutralizing Peptide | sc-398835 P | 100 µg/0.5 ml | $68.00 |