KLK4 Antibody (LX-04): sc-80146

KLK4 Antibody (LX-04) is a mouse monoclonal IgG2b antibody that detects KLK4 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-KLK4 antibody (LX-04) is available as a non-conjugated format. KLK4, a member of the kallikrein family, plays a significant role in various physiological processes, including tissue remodeling and inflammation regulation. KLK4 is primarily expressed in the prostate and participates in proteolytic processing of extracellular matrix components, crucial for maintaining tissue homeostasis and normal cellular functions. Altered KLK4 expression has been linked to several malignancies, including prostate cancer, highlighting KLK4′s potential as a biomarker for cancer diagnostics and therapeutic targets. The human KLK gene family consists of 15 serine proteases located on chromosome 19q13, with specific clusters showing high expression in prostatic and pancreatic tissues. KLK4, along with other kallikreins, responds to steroid hormone regulation, and altered KLK4 expression may contribute to cancer pathogenesis, making KLK4 (LX-04) monoclonal antibody an essential tool for studying cancer biology and related fields.

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KLK4 Antibody (LX-04) References:

1. The new human kallikrein gene family: implications in carcinogenesis.  |  Diamandis, EP., et al. 2000. Trends Endocrinol Metab. 11: 54-60. PMID: 10675891
2. Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4.  |  Yousef, GM., et al. 2000. Biochem Biophys Res Commun. 276: 125-33. PMID: 11006094
3. Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer.  |  Yousef, GM., et al. 2001. J Biol Chem. 276: 53-61. PMID: 11010966
4. The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions.  |  Clements, J., et al. 2001. Biol Chem. 382: 5-14. PMID: 11258672
5. Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies.  |  Yousef, GM., et al. 2001. Cancer Res. 61: 3425-31. PMID: 11309303
6. Expression of the kallikrein gene family in normal and Alzheimer's disease brain.  |  Shimizu-Okabe, C., et al. 2001. Neuroreport. 12: 2747-51. PMID: 11522960
7. Direct evidence that KLK4 is a hydroxyapatite-binding protein.  |  Perez, VA., et al. 2018. Biochem Biophys Res Commun. 495: 1896-1900. PMID: 29229389
8. KLK4 Induces Anti-Tumor Effects in Human Xenograft Mouse Models of Orthotopic and Metastatic Prostate Cancer.  |  Tse, BW., et al. 2020. Cancers (Basel). 12: PMID: 33255452
9. A KLK4 proteinase substrate capture approach to antagonize PAR1.  |  Rabinovitch, E., et al. 2021. Sci Rep. 11: 16170. PMID: 34373558
10. Novel KLK4 Mutations Cause Hypomaturation Amelogenesis Imperfecta.  |  Lee, Y., et al. 2022. J Pers Med. 12: PMID: 35207639
11. KLK4 Silencing Inhibits the Growth of Chromophobe Renal Cell Carcinoma through ERK/AKT Signaling Pathway.  |  Fan, B., et al. 2022. Kidney Blood Press Res. 47: 702-710. PMID: 36260980
12. Association of KLK4 rs2235091 polymorphism with susceptibility to dental caries: a systematic review and meta-analysis.  |  Li, Y., et al. 2023. Front Pediatr. 11: 1236000. PMID: 37711595