KLK15 Antibody (JJ12): sc-80145
- KLK15 Antibody (JJ12) is a mouse monoclonal IgG2a KLK15 antibody provided at 100 µg/ml
- raised against KLK15 of human origin, with epitope mapping to amino acids 23-256
- recommended for detection of KLK15 of human origin by WB and IP; non cross-reactive with KLK3, 5-6, 8 or 10-11
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for KLK15 Antibody (JJ12). This work is in progress.
KLK15 Antibody (JJ12) is a mouse monoclonal IgG2a antibody that detects KLK15 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-KLK15 antibody (JJ12) is available as a non-conjugated format. Kallikreins, including KLK15, are part of the serine protease family, which plays a crucial role in various physiological processes, including the regulation of blood pressure, inflammation, and tissue remodeling. KLK15 protein is primarily expressed in the prostate and is involved in the proteolytic processing of other proteins, which is essential for maintaining normal cellular functions. KLK15 has been implicated in cancer biology, as expression levels can be altered in various malignancies, suggesting a potential role in tumor progression and metastasis. The human KLK gene family consists of 15 serine proteases located on chromosome 19q13, with specific clusters exhibiting high expression in prostatic and pancreatic tissues. Understanding the function and regulation of KLK15 is vital, as KLK15 may serve as a biomarker for prostate cancer and other related diseases, providing insights into therapeutic targets and diagnostic applications.
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KLK15 Antibody (JJ12) References:
- The new human kallikrein gene family: implications in carcinogenesis. | Diamandis, EP., et al. 2000. Trends Endocrinol Metab. 11: 54-60. PMID: 10675891
- Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4. | Yousef, GM., et al. 2000. Biochem Biophys Res Commun. 276: 125-33. PMID: 11006094
- Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer. | Yousef, GM., et al. 2001. J Biol Chem. 276: 53-61. PMID: 11010966
- The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions. | Clements, J., et al. 2001. Biol Chem. 382: 5-14. PMID: 11258672
- Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies. | Yousef, GM., et al. 2001. Cancer Res. 61: 3425-31. PMID: 11309303
- Expression of the kallikrein gene family in normal and Alzheimer's disease brain. | Shimizu-Okabe, C., et al. 2001. Neuroreport. 12: 2747-51. PMID: 11522960
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KLK15 Antibody (JJ12) | sc-80145 | 100 µg/ml | $316.00 |