KLHL17 Antibody (H-7): sc-514593
- KLHL17 Antibody (H-7) is a mouse monoclonal IgG2a κ KLHL17 antibody provided at 200 µg/ml
- raised against amino acids 496-580 mapping near the C-terminus of KLHL17 of human origin
- KLHL17 Antibody (H-7) is recommended for detection of KLHL17 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-KLHL17 Antibody (H-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for KLHL17 Antibody (H-7) for WB applications. These reagents are now offered in bundles with KLHL17 Antibody (H-7) (see ordering information below).
KLHL17 Antibody (H-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects KLHL17 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KLHL17 (H-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KLHL17 protein, also known as kelch-like protein 17, is a 642 amino acid protein characterized by the presence of a BACK (BTB/Kelch associated) domain, a BTB (POZ) domain, and six kelch repeats. KLHL17 is predominantly expressed in the brain and plays a crucial role in actin-based neuronal functions by interacting with F-actin, which is essential for maintaining the structural integrity and functionality of neurons. Additionally, KLHL17 interacts with PDZK1, a protein vital for the stability of actin cytoskeletons, as well as with SYNGAP1 and NMDA receptors, highlighting its importance in synaptic signaling and plasticity. The gene encoding KLHL17 is located on human chromosome 1p36.33 and mouse chromosome 4 E2, making KLHL17 a significant target for studies related to neuronal development and function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KLHL17 Antibody (H-7) References:
- The kelch repeat superfamily of proteins: propellers of cell function. | Adams, J., et al. 2000. Trends Cell Biol. 10: 17-24. PMID: 10603472
- Identification and characterization of KLHL4, a novel human homologue of the Drosophila Kelch gene that maps within the X-linked cleft palate and Ankyloglossia (CPX) critical region. | Braybrook, C., et al. 2001. Genomics. 72: 128-36. PMID: 11401425
- Physical and transcriptional mapping of the X-linked cleft palate and ankyloglossia (CPX) critical region. | Braybrook, C., et al. 2001. Hum Genet. 108: 537-45. PMID: 11499681
- Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals. | Prag, S. and Adams, JC. 2003. BMC Bioinformatics. 4: 42. PMID: 13678422
- The BACK domain in BTB-kelch proteins. | Stogios, PJ. and Privé, GG. 2004. Trends Biochem Sci. 29: 634-7. PMID: 15544948
- The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins. | Albagli, O., et al. 1995. Cell Growth Differ. 6: 1193-8. PMID: 8519696
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KLHL17 Antibody (H-7) | sc-514593 | 200 µg/ml | $322.00 | |||
KLHL17 Antibody (H-7): m-IgG Fc BP-HRP Bundle | sc-526379 | 200 µg Ab; 10 µg BP | $361.00 | |||
KLHL17 Antibody (H-7): m-IgG2a BP-HRP Bundle | sc-546612 | 200 µg Ab; 10 µg BP | $361.00 | |||
KLHL17 Antibody (H-7) AC | sc-514593 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KLHL17 Antibody (H-7) HRP | sc-514593 HRP | 200 µg/ml | $322.00 | |||
KLHL17 Antibody (H-7) FITC | sc-514593 FITC | 200 µg/ml | $336.00 | |||
KLHL17 Antibody (H-7) PE | sc-514593 PE | 200 µg/ml | $349.00 | |||
KLHL17 Antibody (H-7) Alexa Fluor® 488 | sc-514593 AF488 | 200 µg/ml | $364.00 | |||
KLHL17 Antibody (H-7) Alexa Fluor® 546 | sc-514593 AF546 | 200 µg/ml | $364.00 | |||
KLHL17 Antibody (H-7) Alexa Fluor® 594 | sc-514593 AF594 | 200 µg/ml | $364.00 | |||
KLHL17 Antibody (H-7) Alexa Fluor® 647 | sc-514593 AF647 | 200 µg/ml | $364.00 | |||
KLHL17 Antibody (H-7) Alexa Fluor® 680 | sc-514593 AF680 | 200 µg/ml | $364.00 | |||
KLHL17 Antibody (H-7) Alexa Fluor® 790 | sc-514593 AF790 | 200 µg/ml | $364.00 |