KIR3DL1/2 Antibody (C-3): sc-515229
- KIR3DL1/2 Antibody (C-3) is a mouse monoclonal IgG1 κ KIR3DL1/2 antibody provided at 200 µg/ml
- raised against amino acids 271-317 mapping near the C-terminus of KIR3DL2 of mouse origin
- KIR3DL1/2 Antibody (C-3) is recommended for detection of KIR3DL1 and KIR3DL2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-KIR3DL1/2 Antibody (C-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for KIR3DL1/2 Antibody (C-3) for WB applications. This reagent is now offered in a bundle with KIR3DL1/2 Antibody (C-3) (see ordering information below).
KIR3DL1/2 Antibody (C-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects KIR3DL1/2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KIR3DL1/2 (C-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The killer immunoglobulin-like receptors (KIRs) play a crucial role in the immune response by regulating the activation and inhibition of natural killer (NK) cells through their interaction with human leukocyte antigen (HLA) class I molecules. Specifically, KIR3DL1 serves as a receptor for HLA-B antigens that possess the Bw4 allele, delivering an inhibitory signal that prevents NK cell-mediated cytotoxicity, thereby maintaining self-tolerance and preventing autoimmunity. KIR3DL1 is a type I transmembrane protein composed of 444 amino acids and features three immunoglobulin-like C2-type domains, which are essential for function and interaction with HLA molecules. The genes encoding human KIR3DL1 and KIR3DL2 are located on chromosome 19, highlighting their importance in the genetic regulation of immune responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KIR3DL1/2 Antibody (C-3) References:
- Diversity of the p70 killer cell inhibitory receptor (KIR3DL) family members in a single individual. | Kwon, D., et al. 2000. Mol Cells. 10: 54-60. PMID: 10774747
- Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. | Martin, MP., et al. 2002. Nat Genet. 31: 429-34. PMID: 12134147
- Interaction between KIR3DL1 and HLA-B*57 supertype alleles influences the progression of HIV-1 infection in a Zambian population. | López-Vázquez, A., et al. 2005. Hum Immunol. 66: 285-9. PMID: 15784466
- Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations. | Lopez-Larrea, C., et al. 2006. Arthritis Res Ther. 8: R101. PMID: 16805919
- Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. | Thananchai, H., et al. 2007. J Immunol. 178: 33-7. PMID: 17182537
- Functional polymorphism of the KIR3DL1/S1 receptor on human NK cells. | O'Connor, GM., et al. 2007. J Immunol. 178: 235-41. PMID: 17182560
- Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. | Martin, MP., et al. 2007. Nat Genet. 39: 733-40. PMID: 17496894
- Multiple transcripts of the killer cell immunoglobulin-like receptor family, KIR3DL1 (NKB1), are expressed by natural killer cells of a single individual. | Vyas, Y., et al. 1998. Tissue Antigens. 52: 510-9. PMID: 9894849
- Organization of the leukocyte receptor cluster (LRC) on human chromosome 19q13.4. | Wende, H., et al. 1999. Mamm Genome. 10: 154-60. PMID: 9922396
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KIR3DL1/2 Antibody (C-3) | sc-515229 | 200 µg/ml | $316.00 | |||
KIR3DL1/2 Antibody (C-3): m-IgG1 BP-HRP Bundle | sc-531802 | 200 µg Ab; 20 µg BP | $354.00 | |||
KIR3DL1/2 Antibody (C-3) AC | sc-515229 AC | 500 µg/ml, 25% agarose | $416.00 | |||
KIR3DL1/2 Antibody (C-3) HRP | sc-515229 HRP | 200 µg/ml | $316.00 | |||
KIR3DL1/2 Antibody (C-3) FITC | sc-515229 FITC | 200 µg/ml | $330.00 | |||
KIR3DL1/2 Antibody (C-3) PE | sc-515229 PE | 200 µg/ml | $343.00 | |||
KIR3DL1/2 Antibody (C-3) Alexa Fluor® 488 | sc-515229 AF488 | 200 µg/ml | $357.00 | |||
KIR3DL1/2 Antibody (C-3) Alexa Fluor® 546 | sc-515229 AF546 | 200 µg/ml | $357.00 | |||
KIR3DL1/2 Antibody (C-3) Alexa Fluor® 594 | sc-515229 AF594 | 200 µg/ml | $357.00 | |||
KIR3DL1/2 Antibody (C-3) Alexa Fluor® 647 | sc-515229 AF647 | 200 µg/ml | $357.00 | |||
KIR3DL1/2 Antibody (C-3) Alexa Fluor® 680 | sc-515229 AF680 | 200 µg/ml | $357.00 | |||
KIR3DL1/2 Antibody (C-3) Alexa Fluor® 790 | sc-515229 AF790 | 200 µg/ml | $357.00 |