KIR3.4 Antibody (8D2): sc-293378

KIR3.4 Antibody (8D2) is a mouse monoclonal IgG2a kappa light chain antibody that detects KIR3.4 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). KIR3.4 (8D2) antibody is available as the non-conjugated form. KIR3.4 protein, also known as GIRK4 or KCNJ5, plays a crucial role in the regulation of neuronal excitability and synaptic transmission by forming G protein-coupled inwardly rectifying potassium channels. These channels are predominantly located in the soma, dendrites, and axons of neurons, particularly in key regions of the brain such as the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex, and thalamus. Proper functioning of KIR3.4 is vital for maintaining the balance of excitatory and inhibitory signals in the brain, which is essential for processes such as learning, memory, and sensory perception. Additionally, KIR3.4 channels are regulated by G protein beta-gamma subunits, which can either enhance or inhibit potassium currents depending on their composition. Notably, KIR3.4 activity can be modulated by post-translational modifications, such as tyrosine phosphorylation, which can lead to channel inactivation and impact neuronal signaling. This makes KIR3.4 not only a key player in neuronal function but also a potential target for therapeutic interventions in neurological disorders.

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KIR3.4 Antibody (8D2) References:

1. TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel.  |  Rogalski, SL., et al. 2000. J Biol Chem. 275: 25082-8. PMID: 10833508
2. Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein beta gamma subunits.  |  Lei, Q., et al. 2000. Proc Natl Acad Sci U S A. 97: 9771-6. PMID: 10944236
3. Activation of alpha 1-adrenoceptors modulates the inwardly rectifying potassium currents of mammalian atrial myocytes.  |  Braun, AP., et al. 1992. Pflugers Arch. 421: 431-9. PMID: 1361052
4. G-protein-gated inward rectifier K+ channel proteins (GIRK1) are present in the soma and dendrites as well as in nerve terminals of specific neurons in the brain.  |  Ponce, A., et al. 1996. J Neurosci. 16: 1990-2001. PMID: 8604043
5. Neurotensin and dopamine D2 activation oppositely regulate the same K+ conductance in rat midbrain dopaminergic neurons.  |  Farkas, RH., et al. 1997. Neurosci Lett. 231: 21-4. PMID: 9280158

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KIR3.4 Antibody (8D2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-KIR3.4 Antibody (8D2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KIR3.4 Antibody (8D2) Specifications

Alternate Product Name: KIR3.4

Product Clone Name: 8D2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 321-419

Epitope Target: KIR3.4

Epitope Species: human

Product Reactivity/Detection: KIR3.4

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for KIR3.4 Antibody (8D2): N/A