KIR2DL4 Antibody (2H6): sc-59278
- KIR2DL4 Antibody (2H6) is a mouse monoclonal IgG2b KIR2DL4 antibody provided at 50 µg/500 µl
- raised against recombinant KIR2DL4 of human origin
- recommended for detection of KIR2DL1, KIR2DL3, KIR2DL4 and KIR2DS4 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for KIR2DL4 Antibody (2H6). This work is in progress.
KIR2DL4 Antibody (2H6) is a mouse monoclonal IgG2b antibody that detects KIR2DL4 protein of human origin by western blotting (WB) and immunoprecipitation (IP). KIR2DL4 (2H6) antibody is available as a non-conjugated format. KIR2DL4 protein, also known as CD158d, plays a crucial role in the immune response by modulating natural killer (NK) cell activity. KIR2DL4 is located on NK cell surfaces and interacts with class I major histocompatibility complex (MHC) molecules on target cells, which is essential for maintaining immune tolerance and preventing autoimmunity. This interaction downregulates NK cell cytotoxicity, allowing for a balanced immune response. KIR2DL4 features a unique structure, including an extracellular region with immunoglobulin-like domains and a cytoplasmic domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM). These structural features enable signaling pathways that lead to NK cell activity inhibition. KIR2DL4 triggers potent interferon-gamma responses while exhibiting weak cytotoxicity in resting NK cells, highlighting a dual role in immune regulation.
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KIR2DL4 Antibody (2H6) References:
- KIR2DL4 (CD158d) genotype influences expression and function in NK cells. | Goodridge, JP., et al. 2003. J Immunol. 171: 1768-74. PMID: 12902476
- KIR2DL4 is an IL-2-regulated NK cell receptor that exhibits limited expression in humans but triggers strong IFN-gamma production. | Kikuchi-Maki, A., et al. 2003. J Immunol. 171: 3415-25. PMID: 14500636
- Cutting edge: KIR2DL4 transduces signals into human NK cells through association with the Fc receptor gamma protein. | Kikuchi-Maki, A., et al. 2005. J Immunol. 174: 3859-63. PMID: 15778339
- Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer cell Ig-like receptors (KIR), of KIR2DL4, and of KIR3DL3. | Trompeter, HI., et al. 2005. J Immunol. 174: 4135-43. PMID: 15778373
- Residues Met76 and Gln79 in HLA-G alpha1 domain involve in KIR2DL4 recognition. | Yan, WH. and Fan, LA. 2005. Cell Res. 15: 176-82. PMID: 15780179
- Genomic characterization of KIR2DL4 in families and unrelated individuals reveals extensive diversity in exon and intron sequences including a common frameshift variation occurring in several alleles. | Gedil, MA., et al. 2005. Tissue Antigens. 65: 402-18. PMID: 15853895
- Rapid production of human KIR2DL4 extracellular domain and verification of its interaction with HLA-G. | Yu, YR., et al. 2006. Biochemistry (Mosc). 71 Suppl 1: S60-4, 4-5. PMID: 16487070
- Investigation of killer cell immunoglobulin-like receptor KIR2DL4 diversity by sequence-based typing in Chinese population. | Zhu, FM., et al. 2006. Tissue Antigens. 67: 214-21. PMID: 16573558
- Investigation of killer cell immunoglobulinlike receptor gene diversity: I. KIR2DL4. | Williams, F., et al. 2004. Hum Immunol. 65: 31-8. PMID: 14700593
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KIR2DL4 Antibody (2H6) | sc-59278 | 50 µg/500 µl | $322.00 |